for centuries, aloe vera has been used by many different cultures. the ancient greeks, the romans, the babylonians, indians and the chinese have all used aloe vera as a medicinal plant. one of the common experimental cancer models is sarcoma-180. when aloe was administered to mice bearing s-180 tumors, the tumor growth was inhibited. aloe vera is a dietary supplement and not a regulated drug. t...

Today, drug safety data collection in India is both manual and electronic with reporting of potential overlapping and duplicate data, which is likely incomplete for further review and analysis. Furthermore, standardized data collection and timelines are not aligned with international standards. Complete coverage of safety data from all sources throughout the life of the drug cannot be ensured. ...

lamotrigine (ltg), a newly developed antiepileptic drug (aed), is efficacious in treating refractory epilepsy. this study was designed to evaluate the efficacy and safety of ltg as add-on therapy in 40 children with refractory epilepsy. the trial was an open-labeled prospective study in children with drug-resistant epilepsy aged <14 years, who had at least 4 seizures per month in spite of recei...

evaluation and improvement of drug management process is essential for patient safety. the present study was performed whit the aim of assessing risk of drug management process in women surgery department of qeh using hfmea method in 2013. a mixed method was used to analys failure modes and their effects with hfmea. to classify failure modes; nursing errors in clinical management model, for cla...

The presentation of the most recent developments in the field of drug safety falls very well within the scope of the Journal of Pharmacovigilance: pharmacogenetics is certainly one of these. It is the study of associations of genetic traits of individuals and their response to drugs and has become an important aspect to be considered both during drug development and in post-marketing surveillan...

T he fourth iteration of the 1992 law that allows the U.S. Food and Drug Administration to levy user fees on drug companies contains several reforms that could create a major change in how the agency monitors the safety of new drugs after they enter the market. Lawmakers are using reauthorization of the Prescription Drug User Fee Act (PDUFA) to overhaul the agency's authorities and responsibili...

The therapeutic safety of an anticancer drug is one of the most important concerns of the physician treating the cancer patient. Half maximal inhibitory concentration (IC50) and hillslope are usually used to represent the strength and sensitivity of an anticancer drug on cancer cells. The therapeutic safety of the anticancer drug can be assessed by comparing the IC50 and hillslope of anticancer...