نتایج جستجو برای: drug toxicity
تعداد نتایج: 637719 فیلتر نتایج به سال:
A number of drugs induce pulmonary injury and subsequently lead to serious lung diseases such as fibrosis the adverse drug reactions. However, an effective preventive approach against drug-induced has not been established due poor understanding common targets in a variety showing toxicity. Epithelial-mesenchymal transition (EMT), cellular phenotypic change epithelial mesenchymal state, contribu...
The purpose of the research is study pharmaco-toxicological properties Ornidazole- and Levamisole hydrochloride-based drug. Materials methods . drug were studied in premises Laboratory Preclinical Studies, Faculty Veterinary Medicine, Stavropol State Agrarian University. Acute chronic toxicity, irritant effect was under Guidelines for Studies Drugs (2012). Hematological studies laboratory anima...
Cytotoxicity is a very complex process affecting multiple pathways. The ability to measure early indicators of toxicity is an essential part of drug discovery. An important approach to the detection of compound toxicity is a multiparametric analysis at the level of individual cells using High Content Analysis (HCA) applications [Abraham et al., 2008]. Such cell-based assays, which assess severa...
The advent of early absorption, distribution, metabolism, excretion, and toxicity (ADMET) screening has increased the attrition rate of weak drug candidates early in the drug-discovery process, and decreased the proportion of compounds failing in clinical trials for ADMET reasons. This paper reviews the history of ADMET screening and its place in pharmaceutical development, and central nervous ...
The recognition of the gut microbial-mammalian metabolic axis and its implications in human metabolic disease opens a new window to understanding the contribution of the gut microbiome to drug metabolism and drug-induced toxicity. The integrative omics approaches, including pharmacometabonomics and metagenomics, have demonstrated great promise for characterizing xenobiotic interventions that ar...
BACKGROUND Identifying predictive biomarkers of drug response is of key importance to improve therapy management and drug selection in cancer therapy. To date, the influence of drug exposure and pharmacogenetic variants on sorafenib-induced toxicity remains poorly documented. The aim of this pharmacokinetic/pharmacodynamic (PK/PD) study was to investigate the relationship between early toxicity...
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