3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a potentially neurotoxic recreational drug of abuse. Though the mechanisms involved are still not completely understood, formation of reactive metabolites and mitochondrial dysfunction contribute to MDMA-related neurotoxicity. Neuronal mitochondrial trafficking, and their targeting to synapses, is essential for proper neuronal function and ...

Lysosome trafficking plays a significant role in tumor invasion, a key event for the development of metastasis. Previous studies from our laboratory have demonstrated that the anterograde (outward) movement of lysosomes to the cell surface in response to certain tumor microenvironment stimulus, such as hepatocyte growth factor (HGF) or acidic extracellular pH (pHe), increases cathepsin B secret...

Trafficking in women is one of the most corrosive forms of human rights violation. It results in the gradual destruction of a woman’s personal identity and her right to live as a free human. The victim is subjected to violence, humiliation and violation of her personal integrity, which may result in life threatening diseases like HIV/AIDS, STDs or lifelong trauma, drug addiction or personality ...

Auxin gradients are established and maintained by polarized distribution of auxin transporters that undergo constitutive endocytic recycling from the PM (plasma membrane) and are essential for the gravitropic response in plants. The present study characterizes an inhibitor of endomembrane protein trafficking, TE1 (trafficking and endocytosis inhibitor 1/TENin1) that reduces gravitropic root ben...

The purpose of the article is to find out way people convicted organized crime use neutralization techniques avoid blame for their crimes and if there a difference in between members organization’s core periphery. study was carried with seven nine same organization drug trafficking. In-depth triangulated interviews police information court documents were used. Inmates make extensive justify con...

Necrosis is induced by ischemic conditions within the core of many solid tumors. Using fluorescent fusion proteins, we provide in vivo evidence of histone trafficking among cancer cells in implanted tumors. In particular, the most abundant H1 isoform (H1.2) was found to be transported from necrotic tumor cells into surrounding viable cells where histones are selectively taken up by energy-depen...

Trafficking of the G protein-coupled receptor (GPCR) Smoothened (Smo) to the primary cilium (PC) is a potential target to inhibit oncogenic Hh pathway activation in a large number of tumors. One drawback is the appearance of Smo mutations that resist drug treatment, which is a common reason for cancer treatment failure. Here, we undertook a high content screen with compounds in preclinical or c...

Chronic myeloid leukemia (CML) is a malignancy of hematopoietic stem cells. The disease is characterized by abnormal (excessive) proliferation and aberrant trafficking of transformed progenitor cells. This includes early release of these cells into the bloodstream of patients, which is likely dueat least in partto adhesion receptor abnormalities that affect the interaction of malignant cells wi...

1.Introduction The activities of many criminal groups cross national boundaries and escape the control of governments and law enforcement agencies. As a result, they are as much part of domestic as of international politics. The problem of transnational crime in Southeast Asia is severe and consists primarily of drug trafficking, illegal migration, terrorism, money laundering, transnational pro...

The blood-brain barrier (BBB) is a physical and metabolic barrier that separates the central nervous system from the peripheral circulation. Central nervous system drug delivery across the BBB is challenging, primarily because of the physical restriction of paracellular diffusion between the endothelial cells that comprise the microvessels of the BBB and the activity of efflux transporters that...