In order to study the initial as well as the final steps in the aromatization of androgens to estrogens, highspecific activity [ 19-CSHs]androstenedione and testosterone were synthesized. Incubations of [ 19-CSHs]androstenedione with human placental microsomes resulted in the generation of [‘Hlwater, as a result of the dual hydroxylation at (2-19, and [’Hlformic acid reflecting final aromatizat...

In this study, we demonstrate a method to quantify biomarker expression that uses an exogenous dual-reporter imaging approach to improve tumor signal detection. The uptake of two fluorophores, one nonspecific and one targeted to the epidermal growth factor receptor (EGFR), were imaged at 1 h in three types of xenograft tumors spanning a range of EGFR expression levels (n=6 in each group). Using...

To date, many efforts have been made to detect lectins in cells by using single imaging techniques. However, only a few dual-labeled glycan-based probes, which integrate advantageous features of two imaging methods to enhance the visualization of biological processes associated with lectins in cells, have been reported. Herein we describe the synthesis of dual fluorescence and magnetic resonanc...

the advent of dual-modality pet/ct imaging has revolutionized the practice of clinical oncology, cardiology and neurology by improving lesions localization and the possibility of accurate quantitative analysis. in addition, the use of ct images for ct-based attenuation correction (ctac) allows to decrease the overall scanning time and to create a noise-free attenuation map (μmap). the near simu...

Single photon-emission tomography (SPECT) and indium 111-labeled monoclonal antimyosin Fab fragments were used to measure myocardial infarct size in 12 dogs, six subjected to balloon catheter-induced coronary artery occlusion for 6 hr (late reperfusion) and six subjected to occlusion with reperfusion at 2 hr (early reperfusion). Tomographic imaging was performed 24 hr after the intravenous inje...

Dual-energy CT is an imaging technique that has been known and extensively studied for many decades [1-8]. However, due to various technical challenges, only recently has dual-energy CT imaging become a reality. Recent advances in CT scanner technologies have generated a renewed interest in dual-energy CT [9-14], which has led to the commercialization of dual-energy CT systems available for rou...