Binding of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells. Here, we report the structure of the active form of human ORC determined by X-ray crystallography and cryo-electron microscopy. The complex is composed of an ORC1/4/5 motor module lobe in an organization reminiscent of the DNA pol...

Introduction Existing literature suggests that organizational readiness for change (ORC) can influence implementing and sustaining an intervention program. Individual attitude toward innovation is one of the important components of ORC. There is a growing research effort to identify facilitators and barriers regarding positive attitudes toward innovation in clinical settings. The current study ...

AIM The aim of the study was to compare the number of nodes dissected during laparoscopic and open radical cystoprostatectomy in men or anterior exenteration in women due to muscle invasive bladder urothelial cancer (IBC). MATERIAL AND METHODS Fifty-one patients treated with laparoscopic radical cystectomy (LRC) and 63 with open radical cystectomy (ORC) were compared. The LRC group consisted ...

CONTEXT Although open radical cystectomy (ORC) is still the standard approach, laparoscopic radical cystectomy (LRC) and robot-assisted radical cystectomy (RARC) have gained popularity. OBJECTIVE To report a systematic literature review and cumulative analysis of perioperative outcomes and complications of RARC in comparison with ORC and LRC. EVIDENCE ACQUISITION Medline, Scopus, and Web of...

A thermodynamic limitation of single-component working fluids in organic Rankine cycles (ORCs) is the large exergy destruction (and, consequently, useful power loss) associated with evaporation and condensation. Due to their non-isothermal phasechange behaviour, non-azeotropic working-fluid mixtures have shown reduced exergy losses, leading to improved cycle efficiencies and power outputs. Thes...

Higher cerebral functions are based upon a dynamic organization of neuronal networks. To form synaptic connections and to continuously re-shape them in a process of ongoing structural adaptation, neurons must permanently withdraw from the cell cycle. In other words, synaptic plasticity can only occur on the expense of the ability to proliferate. Previously, we have put forward a hypothesis, coi...

In chronic wounds, excess levels and activity of proteases such as elastase and plasmin have been detected. Oxidised regenerated cellulose/collagen matrix (ORC/collagen matrix) has been reported to ameliorate the wound microenvironment by binding and inactivating excess proteases in wound exudates. In this study, the levels and activity of elastase and plasmin in wound exudates of pressure sore...

The reverse engineering of a skeleton based programming environment and redesign to distribute management activities of the system and thereby remove a potential single point of failure is considered. The Orc notation is used to facilitate abstraction of the design and analysis of its properties. It is argued that Orc is particularly suited to this role as this type of management is essentially...

ORC (Organic Rankine Cycle) has potential of reducing consumption of fossil fuels and has many favorable characteristics to exploit low-temperature heat sources. In this work thermodynamic performance of ORC with regeneration is comparatively assessed for various working fluids. Special attention is paid to the effects of system parameters such as the turbine inlet pressure on the characteristi...

Loading of the six related Minichromosome Maintenance (MCM) proteins as head-to-head double hexamers during DNA replication origin licensing is crucial for ensuring once-per-cell-cycle DNA replication in eukaryotic cells. Assembly of these prereplicative complexes (pre-RCs) requires the Origin Recognition Complex (ORC), Cdc6, and Cdt1. ORC, Cdc6, and MCM are members of the AAA+ family of ATPase...