Motivated by a problem in large scale climate data analysis, we consider the problem of maximum a posteriori (MAP) inference in graphical models with millions of nodes. While progress has been made in recent years, existing MAP inference algorithms are inherently sequential and hence do not scale well. In this paper, we present a parallel MAP inference algorithm called KL-ADM based on two ideas...

A method for detecting intrinsic slow variables in high-dimensional stochastic chemical reaction networks is developed and analyzed. It combines anisotropic diffusion maps (ADM) with approximations based on the chemical Langevin equation (CLE). The resulting approach, called ADM-CLE, has the potential of being more efficient than the ADM method for a large class of chemical reaction systems, be...

We consider the linearly constrained separable convex programming whose objective function is separable into m individual convex functions with non-overlapping variables. The alternating direction method (ADM) has been well studied in the literature for the special case m = 2. But the convergence of extending ADM to the general case m ≥ 3 is still open. In this paper, we show that the straightf...

Endothelin-1 (ET-1) and adrenomedullin (ADM) are circulating vasoactive peptides involved in vascular homeostasis and endothelial function. Elevated levels of plasma ET-1 and ADM, and their biologically stable surrogates, C-terminal-pro-endothelin-1 (CT-pro-ET-1) and midregional proadrenomedullin (MR-pro-ADM), are predictors of cardiac death and heart failure. We studied the association of comm...

Adrenomedullin (ADM) is upregulated in cardiac tissue under various pathophysiological conditions. However, the direct inotropic effect of ADM on normal and compromised cardiomyocytes is not clear. In rat ventricular myocytes, ADM produced an initial (<30 min) increase in cell shortening and Ca(2+) transient and, on prolonged incubation (>1 h), a marked decrease in cell shortening and Ca(2+) tr...

BACKGROUND/AIMS Intermedin (IMD) is a novel peptide with significant vasodilator and cardiac protective actions similar to the related peptide adrenomedullin (ADM). Unlike those of ADM the actions and expression of IMD in endothelial cells are poorly characterised. ADM expression can be increased during cardiovascular disease/stress in vitro and in vivo where it may have a role in several cardi...

Adrenomedullin (ADM) acts in a site-specific manner within autonomic centers of the brain to modulate mean arterial pressure (MAP). To determine the role of ADM in the pontine autonomic center, the lateral parabrachial nucleus (LPBN), we used urethane-anesthetized adult Sprague-Dawley male rats to test the hypothesis that ADM increases MAP at this site through glutamate- and nitric oxide (NO)-d...

Omnidirectional, supercardioid, and adaptive directional microphones (ADM) were evaluated in combination with the ADRO amplification scheme for eight participants with moderate sloping hearing losses. The ADM produced better speech perception scores than the other two microphones in all noise conditions. Participants performed the Hearing in Noise Test sentences at -4.5 dB SNR or better, which ...

Acellular dermal matrix (ADM) has been in clinical use for decades in numerous surgical applications. The ability for ADM to promote cellular repopulation, revascularisation and tissue regeneration is well documented. Adipose stem cells have the ability to differentiate into mesenchymal tissue types, including bone and cartilage. The aim of this study was to investigate the potential interactio...