Introduction: Peptic ulcer disease is still the major cause of gastro-intestinal perforation despite major improvements in both diagnostic and therapeutic strategies. While the diagnosis of a perforated ulcer is straightforward in typical cases, its clinical onset may be subtle because of co-morbidites and/or concurrent therapies. Case presentation: We report a case of a 53-year-old Caucasian m...

Helicobacter pylori (H pylori) raises serum gastrin but it is unclear whether this stimulates increased acid secretion. Gastrin mediated acid secretion and plasma gastrin after the intravenous infusion of gastrin releasing peptide was studied in nine H pylori negative and nine H pylori positive healthy volunteers, and in 11 duodenal ulcer patients. Nine of the last group were re-examined one mo...

Stomal Ulceration Stomal ulceration may follow anastomosis of the stomach to any other part of the alimentary canal. I have indicated in my first lecture that by I954, stomal ulceration had followed in over 50 per cent. of the cases in which I had carried out a gastrojejunostomy for duodenal ulcer in I943. In such cases at the second operation, the duodenal ulcer, although often reported as act...

The rate of gastric secretion probably depends upon a balance between secretory and inhibitory stimuli; increase of the former or decrease of the latter may lead to excessive acid production (Thompson, 1962). As a possible cause of duodenal ulcer more attention has hitherto been given to increased excitatory than to impaired inhibitory mechanisms. Inhibitory processes originating in the duodenu...

Much of the confusion of thought and teaching which now exists regarding the surgical management of patients suffering from chronic gastric and chronic duodenal ulcer arises from the fact that in recent years it has become customary to class these two conditions together as one disease -peptic ulcer. It is true that chronic gastric and chronic duodenal ulcer have certain features in common; the...

Introduction: In Ramadan, healthy adult Muslims are obliged to fast. Prolonged fasting increase gastric acid and pepsin levels, which promote the risk of duodenal ulcer perforation (DUP). Effects of Ramadan fasting on DUP have not been thoroughly studied yet, and the limited number of studies investigating the impact of Ramadan fasting on DUP yielded discrepant results. This study aimed to eval...

INTRODUCTION Recent epidemiological evidence supports a strong relationship between Helicobacter pylori infection and gastric cancer [1-11]. The relative risk for cancer with an infection of five years and over is in the region of three to six (Table 1). The identification of almost universal coexistence of H. pylori related antral gastritis in patients with duodenal ulcer disease [12, 13] and ...

OBJECTIVE To determine whether one week's drug treatment is sufficient to eradicate Helicobacter pylori in patients with duodenal ulcer. DESIGN Single blind, randomised controlled trial. SETTING Specialised ulcer clinic in a teaching hospital. PATIENTS 155 patients with H pylori and a duodenal ulcer verified endoscopically which had either bled within the previous 24 hours or was causing ...

Crohn's disease (CD) may involve any part of the gastrointestinal tract, from the mouth to the anus. Approximately >90% of cases occur in the small bowel and colon. Upper gastrointestinal involvement, especially duodenal manifestation, is relatively rare. Therefore, adequate medical treatment for duodenal CD has not yet been established. We report a case of CD with duodenal involvement. A 46-ye...

Antibiotics, commonly amoxycillin, tetracycline, metronidazole and clarithromycin, are presently used in combination with anti-ulcer agents such as omeprazole, colloidal bismuth subcitrate, and sucralfate to treat Helicobacter pylori infection in patients with peptic ulcer, and compelling evidence has accumulated that eradication of the organism prevents duodenal ulcer relapse. The latest combi...