Among different polymers, chitosan, the N-deacetylated product of the polysaccharide chitin, is gaining increasing importance in medical and pharmaceutical applications due to its good mucoadhesion and absorption enhancing ability. Moreover, chitosan shows the ability to form hydrogels able to control the rate of drug release from the delivery system as well as protect the drug from chemical an...

The purpose of the study was to develop Tizanidine HCl (TZN) and Meloxicam (MLX) loaded bilayer mucoadhesive films intended for buccal administration, aiming to enhance the bioavailability. Bilayer films were prepared by solvent evaporation technique selecting arabinoxylan (ARX) as a sustained release (SR) layer forming polymer and hydroxypropyl methylcellulose (HPMC) E-15 as an immediate relea...

This study aimed to develop a suitable buccal mucoadhesive nanoparticle (NP) formulation containing fluconazole for the local treatment of oral candidiasis. The suitability of the prepared formulations was assessed by means of particle size (PS), polydispersity index, and zeta potential measurements, morphology analysis, mucoadhesion studies, drug entrapment efficiency (EE), in vitro drug relea...

Objective: The objective of this research was to formulate and evaluate pectin and HPMC different grades mucoadhesive microspheres in combination with sodium alginate for controlled release of maraviroc. Methods: The maraviroc mucoadhesive microspheres was successfully developed by Ionotropic gelation technique, using sodium alginate, pectin, HPMC K4, K15, and K100 as mucoadhesive polymer in va...

INTRODUCTION Metformin is an oral anti-diabetic drug in the biguanide class. The goal of this study was to develop gastric-retentive MH discs in order to prolong the retention of drug in gastric mucosa. METHODS Two groups of metformin hydrochloride (MH) mucoadhesive gastroretentive discs were prepared: (a) bilayered discs prepared by direct compression of powders containing polymers as Carbop...

The aim of the present study was to formulate and evaluate nystatin containing thermosensitive mucoadhesive gel for vaginal drug delivery to achieve prolonging the residence time, sustained drug release, enhancing efficacy, decreasing recurrence, and increasing patient compliance in the treatment for vaginal candidiasis. Here nystatin (1%) as a model drug. A 3 full factorial design was employed...

The development of biodegradable nanoparticles is an important tool for the biological transport chemical compounds. nanoencapsulation reduces biopharmaceutical and pharmacokinetic drawbacks compounds enhances their properties. Naturally occurring polymers such as proteins polysaccharides have been widely applied in nanostructured systems several therapeutic agents. Among them chitosan, a crust...

Abstract: Objectives: The ambition of this study is to find the mucoadhesive assets Pistacia lentiscus plant gum (mastic gum) by combining it into microspheres with Amoxicillin Trihydrate (ATH). Significance: Due its short stomach residence duration, ATH efficient against H. pylori but can be improved creating Mucoadhesive Microspheres (MMS) that keep trihydrate in stomach. In study, has been e...

Lithium containing droplet and cluster targets irradiated by laser pulses are proposed as prospective source of for soft x-ray lithography. Analytical model and simulations show that laser with repetition rate of several MHz with energy of several mJ and pulse duration 10 ps is required.

We show that according to the GRB internal shock model the pulse duration and the interval between neighboring pulses are correlated and have a similar distribution. We analyze a sample of bright long bursts and find that the pulses duration have a lognormal distribution while the intervals has an excess of long intervals (relative to lognormal distribution). This excess can be explained by the...