Bowen’s disease (BD) is a non-melanoma skin cancer with several histological subtypes. Herein we describe a case of a 35-year-old woman with a 4-cm diameter crusted plaque on the parietal scalp region. She had the lesion for 2 years. It had previously been histologically diagnosed as pemphigus vulgaris and only treated with a topical cream. The lesion progressively became thicker and larger. A ...

In third-world countries, cervical cancer is the most prevalent and leading cause of death. It affected by a variety factors, including smoking, poor nutritional status, immunological inadequacy, prolonged use contraception. The Pap smear test, which intended to prevent cancer, finds preneoplastic changes in epithelial cells. This study framework classified cells from smears into five specified...

: Pseudoangiosarcomatous squamous cell carcinoma, also called pseudovascular, pseudoangiomatoid or adenoid pseudovascular is an uncommon and highly aggressive variant of carcinoma. Histologically, it characterized by proliferation atypical keratinocytes with acantholysis formation spaces, forming anastomosed channels lined neoplastic cells that invade the dermis. These are positive for cytokera...

West Nile Virus (WNV) is a leading cause of viral encephalitis in the United States. Infected mosquitos deliver virus to skin before moves draining lymph nodes establish systemic infection. In vitro studies human keratinocytes and vivo mice suggest role for replication, rashes have been reported half WNV patients, but early stages infection patients remain incompletely understood. We report 58-...

Pemphigus herpetiformis (PH) is an uncommon variant of pemphigus that accounts for an estimated 6% to 7.2% of all cases of this skin disorder. The term pemphigus herpetiformis was coined by Jablonska et al. in 1975 to describe a entity that was clinically similar to dermatitis herpetiformis, showed acantholysis on biopsy, and responded to sulfapyridine. The authors considered that PH was a vari...

Dear Editor, We report the case of a Japanese man with Dari-er's disease (DD) that affected the esophagus as well as the skin. A 49-year-old man, who was diagnosed with DD 19 years earlier, visited us again in October 2008 because his skin lesions had exacerbated. Physical examination revealed reddish-brown crusted fol-licular papules mostly coalesced to produce irregularly shaped warty plaques...

Pemphigus foliaceus (PF) is characterized by acantholysis determined by IgG4 binding to desmoglein I, a 160-kDa desmosomal glycoprotein. To investigate the immunopathological aspects of Brazilian PF, we determined levels of serum cytokines in patients with PF. Twenty-five patients with PF and a control group consisting of 10 healthy individuals were studied. Serum IL-2, IL-4, IL-5, IL-10, IL-12...

Binding of anti-cell surface pemphigus autoantibodies to cultured human epidermal cells stimulates synthesis and secretion of plasminogen activator (PA). Increases in PA activity were detected within 6 h of the addition of IgG and stimulation was dependent upon IgG concentration. Stimulation of PA activity was inhibited by cycloheximide, which indicates that synthesis of protein was necessary. ...