background: the majority of dyspeptic patients do not have identifiable disease, which is also known as functional dyspepsia. the therapeutic approach to patients with functional dyspepsia is still a matter of debate; prokinetic agents are commonly used for symptom relief. this study aims to evaluate the efficacy of domperidone and pyridostigmine (an inhibitor of cholinesterase) in patients wit...

patients presented with dyspepsia compared with 13 (65%) of the 20 patients in the same age group who had not taken the drugs (p<0-001, x2 test). The patients who had taken the drugs therefore constituted 81% (30/37) of those without dyspepsia. In the group aged 65-74 who had taken non-steroidal anti-inflammatory drugs the numbers with and without dyspepsia were similar. Overall, most of the pa...

Up to 40% of individuals complain of dyspepsia but only 25% of these present to their general practitioner. If symptoms have been present for a relatively short period the majority can be managed by reassurance and symptomatic treatment. Those with a longer history require empirical treatment with more powerful medication, endoscopy, testing for Helicobacter pylori, or a combination of these ap...

BACKGROUND/AIMS The precise mechanism of functional dyspepsia is yet to be elucidated. Helicobacter pylori infection and psychiatric disorders are implicated in the etiology. We aimed to determine the prevalence of psychiatric co-morbid disorders in patients with Helicobacter pylori-positive functional dyspepsia and the impact of existing psychiatric disorders on symptomatic response following ...

AIM To perform a meta-analysis evaluating the efficacy of H2-receptor antagonists in functional (nonulcer) dyspepsia. SELECTION OF STUDIES A Medline search was used to identify placebo controlled randomized clinical trials, using the subject headings dyspepsia and H2-receptor antagonist. OUTCOME MEASURES Global assessment by the patient of dyspepsia symptoms, improvement of epigastric pain ...

Although patients with functional dyspepsia complain of epigastric symptoms, the relation between these symptoms and gastric motility remains controversial. There are few reports on the clinical course of functional dyspepsia, including changes in gastric motility, observed over a considerably long period. We conducted a study to examine association between changes in symptoms and changes in ul...

CONTEXT Validated questionnaires are essential tools to be utilized in epidemiological research. At the moment there are no Rome III diagnostic questionnaires translated to Portuguese. OBJECTIVE To validate the Portuguese version of the Rome III Diagnostic Questionnaire for Functional Dyspepsia. METHODS The questionnaire has been translated following the Rome III recommendations. Hundred an...

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Gastroesophageal reflux disease (GERD) is the main known etiological factor for Barrett’s esophagus (BE), and BE is the precursor lesion of esophageal adenocarcinoma. The prevalence of BE is reported mostly from gastroenterology centers and there are only a few reported cases from outpatients with dyspepsia. A large number of patients with GERD have degrees of dyspepsia. This study primarily ai...