Using sapje zebrafish which lack dystrophin, we have assessed both the quantitation of muscle damage in dystrophic fish, and the efficacy of the proteasomal inhibitor MG132 in reducing the dystrophic symptoms. Fourier analysis of birefringence patterns in normal and dystrophic fish was found to be a simple and reliable quantitative measure of muscle damage. MG132, as in mdx mouse, was found to ...

Rod outer segment renewal rate was studied by autoradiographic technique in both the Wistar rat (control) and the Royal College of Surgeons (RCS) dystrophic rat. The dystrophic rat showed normal renewal rate until age 18 days, whereupon further outer segment disc movement slowed and a previously established retrograde degeneration of outer segments progressed. The dystrophic rat differed from t...

Using sapje zebrafish which lack dystrophin, we have assessed both the quantitation of muscle damage in dystrophic fish, and the efficacy of the proteasomal inhibitor MG132 in reducing the dystrophic symptoms. Fourier analysis of birefringence patterns in normal and dystrophic fish was found to be a simple and reliable quantitative measure of muscle damage. MG132, as in mdx mouse, was found to ...

Dystrophic calcifications have been detected in the prostatic fossa, especially after de-obstructing procedures or radiotherapy for prostate cancer. These calcifications can be recalcitrant in patients with poor tissue healing. Hyperbaric Oxygen (HBO) therapy has multiple applications in urology but has not been reported as a treatment of recalcitrant dystrophic calcifications of the prostatic ...

Epidermolysis bullosa (EB) encompasses a group of inherited blistering skin disorders classified into three main subtypes of simplex, junctional and dystrophic. In recent years there have been substantial advances in our understanding of the molecular basis of these conditions and in the management of such patients. In spite of this progress, squamous cell carcinoma (SCC) is still a major cause...