BACKGROUND Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) gene is an inhibitor of apoptosis that expresses in human embryonic tissues but it is absent in most healthy adult tissues. The copy number of BIRC5 has been indicated to be highly increased in tumor tissues; however, its association with the age of onset in breast cancer is not well understood. METHODS Forty tumor tiss...

The fact that reproductive factors have significant influence on the risk of breast cancer is well known. Early age of first full-term birth is highly protective against late-onset breast cancers, but each pregnancy, including the first one, increases the risk of early-onset breast cancer. Estradiol and progesterone induce receptor activator of NF-kappa B ligand (RANKL) in estrogen receptor (ER...

The genetic factors known to be involved in breast cancer risk comprise about 30 genes. These include the high-penetrance early-onset breast cancer genes, BRCA1 and BRCA2, a number of rare cancer syndrome genes, and rare genes with more moderate penetrance. A larger group of common variants has more recently been identified through genome-wide association studies. Quite a number of these common...

objective: to assess the level of awareness on breast cancer among women of reproductive age. materials and methods: a cross-sectional descriptive study was conducted in opd of dhaka medical college hospital among the 175 respondents by face to face interview using pretested semi structured questionnaire. results: one forth (23%) aged 21-25 years, mostly muslim (86.3%), housewives (72.57%), had...

Genome-Wide Association Studies (GWAS) have begun to investigate associations between inherited genetic variations and breast cancer prognosis. Here, we report our findings from aGWAS conducted in 536 patients with early-onset breast cancer aged 40 or less at diagnosis and with a mean follow-up period of 4.1 years (SD1⁄4 1.96). Patients were selected from the Prospective Study of Outcomes in Sp...

Background and purpose The potentially increased risk of extrathymic cancers in myasthenia gravis (MG) remains uncertain. We present the occurrence cancer diagnoses different MG subgroups. Methods conducted a nationwide Swedish register-based cohort study, including patients who had their first diagnosis or prescription acetylcholine esterase inhibitors between years 2006 2018. Timing subtypes ...

Breast cancer is the most commonly diagnosed cancer in women world wide (Parkin and Whelan, 2000). A rapid rise in annual incidence rate of breast cancer has been observed between 1975-1990 in Asian and African than North American and European women (Sasco, 2001). The published data from Karachi Cancer Registry, the reported incidence of breast cancer was 34.6% and observed as the most common c...

the value of clinical use of tumor markers cea and ca15-3 for early detection of recurrent breast cancer still is a controversial. this study was investigated relationship between tumor markers cea and ca15-3 and recurrence breast cancer. data regarding 147 women who had breast cancer were entered into the study. patients were reviewed for 120 months after treatment. maximum time for relapse wa...

results strong participation was associated with a younger age, higher educational level, higher incomes, previous history of cancer, previous family history of cancer, one or two prior mammographies, more correct recognitions of mammography, recall rate, and breast cancer risk. if the false-positive result occurred, 83.9%, 81.9% and 77.3% of the women agreed or strongly agreed to participate i...