An outstanding question in human genetics has been the degree to which adaptation occurs from standing genetic variation or from de novo mutations. Here, we combine several common statistics used to detect selection in an Approximate Bayesian Computation (ABC) framework, with the goal of discriminating between models of selection and providing estimates of the age of selected alleles and the se...

During organogenesis, cell fate specification and patterning are regulated by signaling centers, specialized clusters of morphogen-expressing cells. In many organs, initiation of development is marked by bud formation, but the cellular mechanisms involved are ill defined. Here, we use the mouse incisor tooth as a model to study budding morphogenesis. We show that a group of nonproliferative epi...

We characterized a movement disorder of Chinese Crested dogs clinically and pathologically indistinguishable from canine multiple system degeneration (CMSD) previously recognized in Kerry Blue Terriers. This fatal disease segregated as an autosomal recessive in a 51-dog pedigree of both breeds and their crosses. The occurrence of affected dogs among first-generation crosses demonstrated that th...

Hair follicle morphogenesis depends on Wnt, Shh, Notch, BMP and other signaling pathways interplay between epithelial and mesenchymal cells. The Wnt pathway plays an essential role during hair follicle induction, Shh is involved in morphogenesis and late stage differentiation, Notch signaling determines stem cell fate while BMP is involved in cellular differentiation. The Wnt pathway is conside...

Peraturan Presiden Republik Indonesia Nomor 14 Tahun 2021 Tentang Perubahan Atas 99 2020 tentang Pengadaan Vaksin dan Pelaksanaan Vaksinasi dalam Rangka Penanggulangan Pandemi Corona COVID-19 (Perpres 14/2021) telah diterbitkan oleh Presiden. Perpres tersebut untuk pengadaan vaksin serta pelaksanaan vaksinasi di Indonesia. Pada ketentuan Pasal 11 Ayat (1) Dalam hal terjadi keadaan kahar (force ...

Keberadaan obat tradisional telah sering dikonsumsi dan dipergunakan oleh masyarakat Indonesia. Demikian pula dengan Sarang Semut (Myrmecodia) merupakan tanaman endemic yang ditemukan di Papua, Tanaman ini biasa menempel pada dahan atau batang tumbuhan lain lebih besar, batangnya menggelembung dalamnya banyak terdapat ruang rongga kecil dihuni semut. Manfaat sarang semut Papua sudah lama diguna...