BACKGROUND Patient outcomes in multiple sclerosis (MS) have generally been measured by their neurological impairment using specific scales such as the Kurtzke Expanded Disability Status Scale (EDSS). However, this scale does not measure the multiple dimensions of health-related quality of life (HRQOL) such as functional status and general well-being, which are also important outcomes along with...

The objective of this study was to evaluate relationships between subjective and objective measures of balance in multiple sclerosis (MS). In 54 subjects with MS, balance was measured objectively with the Sensory Organization Test (SOT) using dynamic posturography and subjectively with the Activities-specific Balance Confidence (ABC) Scale and the Falls Efficacy Scale-International (FES-I). MS-...

Objective: To determine the relationships between urological features of multiple sclerosis (MS) and various disease parameters. Material and Methods: Forty-three patients with MS were evaluated. Urinary complaints, disease duration, urologic symptom duration, time elapsed till urologic symptom, expanded disability status score (EDSS), and bladder functional score (BFS) for each patient were co...

The aim of this study was to analyze: frequency of balance disorder (vertigo and disequilibrium), frequency of abnormalities in auditory evoked potentials (AEP) and magnetic resonance imaging (MRI) changes of the brain in multiple sclerosis (MS) patients with balance disorder, relation of patient's disability status to balance disorder and relation of the changes in MRI of the brainstem to AEP ...

BACKGROUND Multiple sclerosis (MS) has a highly heterogenic course making prediction of long term outcome very difficult. OBJECTIVE The objective was to evaluate current and identify additional clinical factors that are linked to long term outcome of relapsing-remitting MS assessed by disability status 10 years after disease onset. METHODS This observational study included 793 patients with...

Objective. To compare patterns of associations of changes in mental and physical health dimensions of health-related quality of life (HRQoL) over time with relapse occurrence and changes in Expanded Disability Status Scale (EDSS) scores in patients with relapsing multiple sclerosis (RMS). Methods. This 24-month, phase IV, observational study enrolled 334 patients with RMS who received interfero...

BACKGROUND AND PURPOSE Vitamin D deficiency is a recognized risk factor for multiple sclerosis (MS) and is associated with increased disease activity. It has also been proposed that the lower the vitamin D levels are, the higher is the handicap. METHODS To refine the links between vitamin D insufficiency and disability in MS patients, a retrospective cohort analysis was performed including 18...

BACKGROUND Treatment with MD1003 (high-dose biotin) showed promising results in progressive multiple sclerosis (MS) in a pilot open-label study. OBJECTIVE To confirm the efficacy and safety of MD1003 in progressive MS in a double-blind, placebo-controlled study. METHODS Patients (n = 154) with a baseline Expanded Disability Status Scale (EDSS) score of 4.5-7 and evidence of disease worsenin...

BackgroundLow vitamin D levels, tobacco use and high body mass index (BMI) have been linked to adverse disease outcomes in multiple sclerosis (MS), but their influence on long-term disability progression remains unclear. Therefore, we explored whether these modifiable lifestyle factors were associated with 10-year clinical patients MS.MethodsIn this prospective study, a cohort of 88 relapsing-r...

Consumers in current society have become increasingly concerned with the negative impacts their products purchased have on both their individual health and the natural environment. However, consumers have received very little support in their attempt to adopt more eco-effective purchasing habits. There exist environmental decision support systems (EDSS) that allow consumers compare alternatives...