ObjectivesThis cost-effectiveness analysis (CEA) of 4CMenB infant vaccination in England comprehensively considers the broad burden serogroup B invasive meningococcal disease (MenB IMD), which has not been considered, or was only partially considered previous CEAs.MethodsA review MenB CEAs conducted to identify aspects evaluation costs and health outcomes IMD. To inform model structure comprehe...

Surgical carotid endarterectomy (CEA) was long considered the standard approach for the treatment of atherosclerotic carotid artery disease. This was based on results of several randomized trials demonstrating its effectiveness over the best medical therapy. In the past two decades, patients identified high-risk for surgery were offered carotid artery stenting (CAS) as a less invasive option. D...

BACKGROUND To investigate serum carcinoembryonic antigen (CEA) as a prognostic factor for rectal cancer patients receiving pre-operative chemoradiotherapy (CRT). METHODS Between 2000 and 2009, 138 patients with advanced rectal cancer receiving CRT before surgery at our hospital were retrospectively classified into 3 groups: pre-CRT CEA <6 ng/ml (group L; n = 87); pre-CRT CEA ≥ 6 ng/ml and pos...

In a health care system with ever-rising demand and limited resources, economic assessment of medical technologies is important for those who make resource allocation decisions that affect the health of populations. Cost-effectiveness analysis (CEA) is the best developed tool available for comparing the relative health benefits for expenditure among a myriad of available health interventions. ...

High-intensity endurance exercise (HIE) induces negative emotions alongside fatigue, suffering, and changes in cardiovascular responses, these regulations could be important for athletic performance. Previous studies have reported that limbic brain stem regions, including the central nucleus of amygdala (CeA), paraventricular hypothalamus (PVH), tractus solitarii (NTS), play roles emotional res...

Because of heterogeneity treatment effect, decisions based on average measures cost-effectiveness may lead to incorrect recommendations for specific subsets the population. This study examined whether Institute Clinical and Economic Review (ICER), a leading advocate wider use value-based pricing in U.S., accounts patient their assessments. We conducted systematic review 8 ICER reports treatment...

understanding the mechanism of tumor resistance is critical for cancer therapy. in this study, we investigated the effect of carcinoembryonic antigen (cea) overexpression on uv-and 5-fluorouracil (5-fu)-induced apoptosis and autophagy in colorectal cancer cells. we used histone deacetylase (hdac) inhibitor, nab and dna demethylating agent, 5- azacytidine (5-aza) to induce cea expression in ht29...

Economic analyses of treatment options are particularly important to assist treatment decisions in a resource-limited country such as Brazil. Recently, Machado et al. published in this journal a cost-effectiveness analysis (CEA), comparing linezolid versus vancomycin for the treatment of mechanical ventilation-associated nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus...

OBJECTIVE AND DESIGN In order to evaluate the comparative efficacy and safety of carotid angioplasty with or without stent placement (CAS) versus carotid endarterectomy (CEA) we performed a meta-analysis of the presently available randomized studies. MATERIALS AND METHODS A multiple electronic health database search on all randomized trials describing CAS compared with CEA in patients with sy...