BACKGROUND Initiation and titration of human regular U-500 insulin (U-500R) with a dosing algorithm of either thrice daily (TID) or twice daily (BID) improved glycemic control with fewer injections in patients with type 2 diabetes treated with high-dose, high-volume U-100 insulin. The objective of this analysis was to compare patient-reported outcomes between U-500R TID and BID treatment groups...

As our world becomes increasingly digitalized, data centers as operational bases for these technologies lead to a consequent increased release of excess heat into the surrounding environment. This paper studies challenges and opportunities industrial symbiosis between centers’ greenhouse farming, specifically utilizing north Sweden case study region. The region was selected in bid tackle urgent...

Bcl-2 family member Bid is subject to autoinhibition; in the absence of stimuli, its N-terminal region sequesters the proapoptotic Bcl-2 homology 3 (BH3) domain. Upon proteolytic cleavage in its unstructured loop, Bid is activated, although structural data reveal no apparent resulting conformational change. We found that, upon Bid cleavage, the N-terminal fragment (tBid-N) is ubiquitinated and ...

Methods enabling the delivery of proteins into eukaryotic cells are essential to address protein functions. Here we propose broad applications to cell biology for a protein delivery tool based on bacterial type III secretion (T3S). We show that bacterial, viral, and human proteins, fused to the N-terminal fragment of the Yersinia enterocolitica T3S substrate YopE, are effectively delivered into...

We report the solution structure of BID, an intracellular cross-talk agent that can amplify FAS/TNF apoptotic signal through the mitochondria death pathway after Caspase 8 cleavage. BID contains eight alpha helices where two central hydrophobic helices are surrounded by six amphipathic ones. The fold resembles poreforming bacterial toxins and shows similarity to BCL-XL although sequence homolog...

With the rapid depletion of IPv4 protocol in these recent years, IETF introduced IPv6 as a solution to address exhaustion, however, new exists, characteristics have been and threats discovered. Extension Headers are that an emerging re-emerging security is needed be taken into consideration during full migration network. This study revealed up this moment, popular vendors still vulnerable doesn...

Title of dissertation: DESIGN OF DISCRETE AUCTION Pacharasut Sujarittanonta, Doctor of Philosophy, 2010 Dissertation directed by: Professor Peter Cramton Department of Economics Chapter 1: Efficient Design of an Auction with Discrete Bid Levels This paper studies one of auction design issues: the choice of bid levels. Full efficiency is generally unachievable with a discrete auction. Since ther...