Realistic appraisal of paleoclimatic information obtained from a particular location requires accurate knowledge of its paleolatitude defined relative to the Earth's spin-axis. This is crucial to, among others, correctly assess the amount of solar energy received at a location at the moment of sediment deposition. The paleolatitude of an arbitrary location can in principle be reconstructed from...

INTRODUCTION Accurate surgical risk prediction is paramount in clinical shared decision making. Existing risk calculators have limited value in local practice due to lack of validation, complexities and inclusion of non-routine variables. OBJECTIVE We aim to develop a simple, locally derived and validated surgical risk calculator predicting 30-day postsurgical mortality and need for intensive...

The laws of thermodynamics constrain the action of biochemical systems. However, thermodynamic data on biochemical compounds can be difficult to find and is cumbersome to perform calculations with manually. Even simple thermodynamic questions like 'how much Gibbs energy is released by ATP hydrolysis at pH 5?' are complicated excessively by the search for accurate data. To address this problem, ...

Molecular descriptors are widely employed to present molecular characteristics in cheminformatics. Various molecular-descriptor-calculation software programs have been developed. However, users of those programs must contend with several issues, including software bugs, insufficient update frequencies, and software licensing constraints. To address these issues, we propose Mordred, a developed ...

We present an interactive tool, called iscc, for manipulating sets and relations of integer tuples bounded by affine constraints over the set variables, parameters and existentially quantified variables. A distinguishing feature of iscc is that it provides a cardinality operation on sets and relations that computes a symbolic expression in terms of the parameters and domain variables for the nu...

Recombination rate is a key evolutionary parameter that determines the degree to which sites are linked. Estimating recombination rates is thus of crucial importance for population genetic and molecular evolutionary studies. We present here a user-friendly web-based tool that can be used to retrieve recombination rate estimates for single and/or multiple loci in the Drosophila melanogaster geno...

Sahar Fanian, Stephanie K. Young, Mason Mantla*, Anita Daniels and Susan Chatwood Institute for Circumpolar Health Research, Yellowknife, Northwest Territories, Canada; Social & Behavioral Health Science Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Community Action Research Team, Tłı̨chǫ Government, Behchokǫ̀, Northwest Territories, Canada; Depart...

Given four complex matrices $A$‎, ‎$B$‎, ‎$C$ and $D$ where $Ainmathbb{C}^{ntimes n}$‎ ‎and $Dinmathbb{C}^{mtimes m}$ and let the matrix $left(begin{array}{cc}‎ A & B ‎ C & D‎ end{array} right)$ be a normal matrix and‎ assume that $lambda$ is a given complex number‎ ‎that is not eigenvalue of matrix $A$‎. ‎We present a method to calculate the distance norm (with respect to 2-norm) from $D$‎ to ...