A simple, selective and sensitive spectrophotometric method has been developed for the individual and simultaneous determination of Ti(IV) and Mo(VI) using salicylaldehyde p-hydroxybenzoylhydrazone (SAPHBH) in presence of Triton X100, without any prior separation. Beer’s law is obeyed between 0.15-2.0 and 0.20-2.51 μgmL concentration of Ti(IV) and Mo(VI) at 470 and 410 nm, respectively. The mol...

A first-derivative spectrophotometric method for the simultaneous determination of piroxicam (PX) and its major metabolite 5'-hydroxypiroxicam (OH PX) in human plasma is described. The method consists of direct extraction of the two drugs from the plasma samples with hydrochloric and trichloroacetic acid prior to their determination by measuring the first-derivative signals at 337.0 nm for PX a...

UNLABELLED BACKGROUND The new combination of moxifloxacin HCl and cefixime trihydrate is approved for the treatment of lower respiratory tract infections in adults. At initial formulation development and screening stage a fast and reliable method for the dissolution and release testing of moxifloxacin and cefixime were highly desirable. The zero order overlaid UV spectra of moxifloxacin and ...

A simple spectrophotometric method is described for resolving binary mixtures of some food dyes: Amaranth, Brilliant Blue, Sunset Yellow and Tartrazine, using the first-derivative spectra with measurements at zero-crossing wavelengths. Analytical curves are linear up to 20 mg L(-1). Standard deviations of 1.30, 2.22, 1.93 and 0.81% were obtained for synthetic binary mixtures of 2 mg L(-1) of Am...

A new simple and sensitive ratio-spectra first derivative spectrophotometric method was developed for the simultaneous determination of tapentadol hydrochloride (TPH) and paracetamol (PCM) in binary mixtures. The method depends on the use of the first derivative of the ratio-spectra obtained by dividing the absorption spectrum of binary mixture by a standard spectrum of one of the compounds. TP...

A derivative spectrophotometry method was developed to determine enalapril, hydrochlorothiazide, candesartan and walsartan in complex antihypertensive drugs. The pharmaceutical preparations containing hydrochlorothiazide and one of the angiotensin convertase inhibitors were investigated. It was found that the developed method enables the constituents of the investigated drugs to be determined d...

Two-component mixtures of cefsulodin and clavulanic acid were analysed by a first-derivative spectrophotometric method using a zero-crossing technique of measurement. The relative ease offered by this derivative technique for the quantification of these drugs, with closely overlapping spectral bands, was clearly demonstrated. As the absorption band of clavulanic acid closely overlaps with that ...

A first derivative spectrophotometric (D) and derivative ratio (1DD) methods were utilized to determine raubasine (I) and almitrine dismesylate respectively using methanol as a solvent. A linear relationship was obtained in the range from 6-20 μg ml raubasine for the (D) method and 1024 μg ml almitrine dismesylate for the (DD) method. By applying the proposed methods, it was possible to determi...

A poly(vinyl chloride) membrane based on a new a-dioxime derivative as membrane carrier was prepared andinvestigated as a Cr(III) selective electrode. The electrode exhibits a good potentiometric response for Cr(III)over a wide concentration range 1.0 x 10-6 to 1.0 x 10-1 M with a slope 19.5+0.5 mV/decade and low detectionlimit of 8.9 x 10-7 M. It has a fast response time < 15 s. The best perfo...

The present work describes three spectrophotometric methods for determining two phytoconstituent berberine hydrochloride and eugenol in formulated gels: simultaneous equation method, absorbance correction, zero-crossing derivative method. In the at 263 nm 280 correction method 345 were measured applied to their respective estimation of phosphate buffer emulgel. amplitudes first spectra 252.5 26...