Gold nanoparticles (AuNPs) are promising candidates for medical diagnostics and therapeutics, due to their chemical stability, optical properties, and ease of functionalization. Citrate-stabilized reference materials also have potential as negative controls in toxicology studies of other nanoparticles. Here we examine the impact of 30 nm particles on the in vitro development of rat-cortex neura...

Noblemetal clusters (Pt, Pd, Rh, Ir, Re, and Ag) are selectively encapsulatedwithin LTA voids via hydrothermal synthesis usingmetal precursorswith ligands (NH3 for Pt and Ir; ethylenediamine for Pd, Rh, Re andAg) that prevent their premature precipitation as colloidal oxyhydroxides. Such stability appears to be necessary and sufficient for successful encapsulation of cationic precursors during ...

background: the most important limitation of glass ionomer cements (gics) is the weak mechanical properties. our previous research showed that higher mechanical properties could be achieved by addition of forsterite (mg2sio4) nanoparticles to ceramic part of gic. the objective of the present study was to fabricate a glass ionomer- mg2sio4 nanocomposite and to evaluate the effect of addition of ...

Ferroelectric oxides, such as lead zirconate titanate, have proved invaluable due to their excellent dielectric and piezoelectric properties. These classes of materials possess a large electric polarization below the Curie temperature. Regions of the crystal lattice having different directions of polarization are separated by nano-scale interfaces known as domainwalls. These interfaces, which c...

BACKGROUND C3 glomerulopathy (C3GP) is characterized by deposition of complement C3 with absence/traces of immunoglobulins in the glomeruli and categorized into dense deposit disease (DDD), C3 glomerulonephritis (C3GN), complement factor H related protein 5(CFHR5) nephropathy etc. Collaborative efforts of pathologists, complement biologists and nephrologists worldwide are expanding the histomor...

Polymer-nanoclay composite materials have attracted considerable interest among materials scientists recently because of the pioneering work carried out by a research group in the Toyota Central Research Laboratories. The group applied a nylon-montmorillonite clay nanocomposite as an under-the-hood structural part in the engine compartment of an automobile with significantly improved tensile st...

Purpose: To investigate the expression and exogenous effect of leptin hormone in diseased parathyroid glands at a basic science and clinical level. Introduction: Hyperparathyroidism (HPTH) is a common endocrine problem affecting 1 in 500 individuals who are typically female and over the age of 60. Combined effects of low calcium and vitamin D stimulating parathyroid activity and excess PTH secr...

INVESTIGATION OF THE PHARMACOKINETICS AND LOCAL AND SYSTEMIC MORBIDITY OF A GENTAMICIN IMPREGNATED COLLAGEN SPONGE IMPLANTED IN THE CANINE STIFLE Galina Merete Hayes Advisors: University of Guelph, 2013 Dr Tom Gibson Dr Noel Moens This thesis is an investigation of a gentamicin impregnated collagen sponge (GICS) product implanted into an inflamed canine stifle joint. Project goals were to deter...

Aspirin, acetyl salicylic acid, damages gastric mucosal cells. This effect is considered related to its inhibition of prostaglandin synthesis. On the other hand, sodium salicylate has been reported to be cytoprotective against drug damage to gastric mucosa in vivo. One reason for this difference is that salicylic acid, unlike acetyl salicylic acid does not inhibit prostaglandin synthesis by gas...

PURPOSE To investigate long-term changes in the anterior segment of primate eyes treated for one year with different prostaglandin agonists and a prostamide. The results were compared with those obtained after vehicle treatment and in untreated controls. METHODS Sixteen young cynomolgus monkeys were unilaterally topically treated for 1 year with either bimatoprost 0.03% (prostamide), sulprost...