Calcium imaging is a versatile experimental approach capable of resolving single neurons with single-cell spatial resolution in the brain. Electrophysiological recordings provide high temporal, but limited spatial resolution, because of the geometrical inaccessibility of the brain. An approach that integrates the advantages of both techniques could provide new insights into functions of neural ...

Within 2 weeks of decapitation, Hydrobia ulvae was able to regenerate new head structures including buccal ganglia. It was also capable of regenerating propodial ganglia after anterior foot amputation. The functional regeneration of the buccal ganglia was demonstrated by behavioural observations and by electrophysiological experiments. The presence of the oesophagus was shown to be important fo...

Clinical signs of upper motor neuron (UMN) involvement are an important component in supporting the diagnosis of amyotrophic lateral sclerosis (ALS), but are often not easily appreciated in a limb that is concurrently affected by muscle wasting and lower motor neuron degeneration, particularly in the early symptomatic stages of ALS. Whilst recent criteria have been proposed to facilitate improv...

It has been shown that the maxillary palps of Locusta migratoria (L.) play an important part in food selection when the insect has not been deprived of food for a long period (Blaney & Chapman, 1970; Blaney, Chapman & Wilson, 1973). The receptors primarily concerned are those on the flexible dome at the distal tip of the palp, and in the fifth instar larvae of Locusta there are about 370 of the...

Microelectrode techniques were used to study the electrophysiological effects of hypertonic solutions on canine cardiac Purkinje fibers. Tyrode's solution was rendered hyperosmotic by the addition of sucrose to produce 320, 350, 400, and 500 mOsm solutions. Hyperosmotic solutions produced sucrose concentration-dependent hyperpolarization, increased the current required to effect all-or-none dep...

Within 2 weeks of decapitation, Hydrobia ulvae was able to regenerate new head structures including buccal ganglia. It was also capable of regenerating propodial ganglia after anterior foot amputation. The functional regeneration of the buccal ganglia was demonstrated by behavioural observations and by electrophysiological experiments. The presence of the oesophagus was shown to be important fo...

Spike detection and sorting on electrophysiological signals from MEA electrodes is demanding because noise levels are high, and many neurons may be simultaneously recorded by each electrode. In such data, there are always detection failures (false negatives and false positives). We present a new spike detection technique based on Cepstrum of Bispectrum (CoB) and assess it on real neural data. T...

Diagnosis of patients with disorders of consciousness (comprising coma, vegetative state/unresponsive wakefulness syndrome, and minimally conscious state) has long been dependent on unstandardized behavioral tests. The arrival of standardized behavioral tools, and especially the Coma Recovery Scale revised, uncovered a high rate of misdiagnosis. Ancillary techniques, such as brain imaging and e...

Previous studies exploring mental time travel paradigms with functional neuroimaging techniques have uncovered both common and distinct neural correlates of re-experiencing past events or pre-experiencing future events. A gap in the mental time travel literature exists, as paradigms have not explored the affective component of re-experiencing past episodic events; this study explored this spars...

A central question in neuroscience is how interactions between neurons give rise to behavior. In many electrophysiological experiments, the activity of a set of neurons is recorded while sensory stimuli or movement tasks are varied. Tools that aim to reveal underlying interactions between neurons from such data can be extremely useful. Traditionally, neuroscientists have studied these interacti...