Eley HL, Russell ST, Baxter JH, Mukerji P, Tisdale MJ. Signaling pathways initiated by -hydroxy-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli. Am J Physiol Endocrinol Metab 293: E923–E931, 2007. First published July 3, 2007; doi:10.1152/ajpendo.00314.2007.—To investigate the mechanism by which -hydroxy-methylbutyrate (HMB) at...

Febrile convulsions in childhood constitute one of the commonest medical emergencies in paediatric practice. Although the aetiology, clinical picture, treatment and possible sequelae are described and discussed in the standard paediatric literature, little or no mention is made of the exact cerebrospinal fluid (C.S.F.) composition in this condition (Sheldon, 1951; Grulee and Eley, 1952; Collis,...

Although silicon is a constituent of normal animal tissues, silicic acid formed by the dissolution of inhaled quartz particles can induce the formation of pathological lesions in which the normal tissue is replaced by fibrotic tissue arranged concentrically around the silica particles. The mechanism of the change which constitutes the disease, silicosis, is unknown. Schulman & Rideal (1937) dem...

THIS paper describes a continuation of the work of Rosenheim and Adam [1929] on unimolecular films of derivatives of ergosterol, spread on a water surface. Its object is to obtain information as to the properties of the molecules in these films, in the hope of throwing fresh light on the constitution of the various products. While some progress has been made, there are still many points in the ...

ation by the ciliopathy protein Rpgrip1 l is essential for planar cell polarity. J Cell Biol 2012; 198: 927–940 18. Pugacheva EN, Jablonski SA, Hartman TR et al. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 2007; 129: 1351–1363 19. Kim S, Tsiokas L. Cilia and cell cycle re-entry: more than a coincidence. Cell Cycle 2011; 10: 2683–2690 20. Phillips CL, Mille...

The Oxford English Dictionary defines routine as "a regular course or procedure, a more or less mechanical or unvarying performance of certain acts or duties". Over tie past 20 years a chest radio-graph has become a routine part of the assessment of a patient prior to general anaesthesia. It is right that we should periodically confirm, or perhaps question, our reasons for performing any invest...

A review of relevant published reports seems to indicate that in the case of babies suffering from intermittent airway obstruction due to a combination of micrognathia, glossoptosis, and often cleft of hard and soft palate (the Pierre Robin syndrome), successful treatment usually includes surgery of one kind or another. However, some non-surgical methods have been advocated. Pierre Robin (1934)...