Induced pluripotent stem cells (iPSCs), which greatly circumvent the ethical issue of human embryonic stem cells (ESCs), can be induced to differentiate to dopaminergic (DA) neurons, and hence be used as a human disease model for Parkinson's disease (PD). iPSCs can be also utilised to probe the mechanism, and serve as an 'in vivo' platform for drug screening and for cell-replacement therapies. ...

Introduction: Doxorubicin is frequently used for treatment of several types of cancer. Doxorubicin cardiac toxicity has limited the use of this drug. Corticosteroids may prevent doxorubicin induced cardiotoxicity. Therefore the aim of this study was to evaluate mouse embryonic stem cells derived cardiomyocytes as a model to evaluate the effect of Doxorubicin and dexamethasone. Methods: Mouse ...

Because the average human life span has recently increased, the number of patients who are diagnosed with neurodegenerative diseases has escalated. Recent advances in stem cell research have given us access to unlimited numbers of multi-potent or pluripotent cells for screening for new drugs for neurodegenerative diseases. Neural stem cells (NSCs) are a good model with which to screen effective...

background: diabetes is a multi factor disease of metabolic disorders, increasing of blood glucose or hyperglycemia. it can cause by secretion abnormality, insulin function or both. sweet diabetic is most common disease and about 150* 1 05 people are suffered from its thought the world. it is predicted that it will reach up to 300*l06 till 2045 . methods: a descriptive study using logical order...

background: early detection and screening have been successful in reducing mortality in some countries, but not in others. this is most of due to poor management and implementation of inappropriate policies. all of patients with cervical cancer are in developing countries. the effectiveness of screening for cancer of the cervix in these countries is dramatic. it seems that after 50 years pap sm...

background: breast cancer is the most common cancer found in women, and screening is the best way to make an early diagnosis. the aim of this study was to determine the rate of screening mammography and related variables in the mammography center of mousavi hospital, located in zanjan, iran. methods: this was a prospective descriptive study. study sample size was 526 women who were selected by ...

a simple, rapid new technique is described for the electrophoresis of hemo­globin when screening large human populations. the method uses a drop of finger tip's blood dried on a thick filter paper as the specimen. the simplicity of the sampling, tagging, transportation and electrophoresis, provides a reliable procedure for surveys of large population. in our hand 200 specimens were screened dur...

background the mammograms and papanicolaou (pap) test of women aged 25 to 64 years are iran’s national strategy for breast and cervical cancer screening, respectively. widespread primary care services are supplied through a network of primary health centers; nonetheless, little is known about breast and cervical cancer screening-related practices among healthcare workers in hospitals. objective...

Human pluripotent stem cells (hPSCs) represent a promising source of patient-specific cells for disease modeling, drug screens, and cellular therapies. However, the inability to derive engraftable human hematopoietic stem and progenitor cells (HSPCs) has limited their characterization to in vitro assays. We report a strategy to respecify lineage-restricted CD34(+)CD45(+) myeloid precursors deri...

Differentiation of human embryonic stem cells (hESCs) into cardiomyocytes in culture may offer unique opportunities for modeling genetic disorders, screening potentially cardiotoxic pharmaceutical agents or replacing cells of the diseased heart. However, before clinical utility can be realized, numerous hurdles must be overcome. Comprehensive molecular and phenotypic characterization is require...