BACKGROUND It is unclear whether appropriate empiric antimicrobial therapy improves outcomes in patients with bacteremia due to Escherichia coli or Klebsiella. The objective of this study is to assess the impact of appropriate empiric antimicrobial therapy on in-hospital mortality and post-infection length of stay in patients with Escherichia coli or Klebsiella bacteremia while adjusting for im...

Background Increasing antibiotic resistance limits treatment options for gonorrhea. We examined the impact of a hypothetical point-of-care (POC) test reporting antibiotic susceptibility profiles on slowing resistance spread. Methods A mathematical model describing gonorrhea transmission incorporated resistance emergence probabilities and fitness costs associated with resistance based on chara...

An infectious wart of foot in a patient with diabetics is a medical challenge, and it gets worse when aggravated with burns. We present a case of a 67-year-old Pakistani man, diabetic for 20 years presented at our healthcare centre. While awaiting his culture sensitivity report, he was prescribed an empiric antibiotic therapy. Patient then travelled to Saudi Arabia for pilgrimage 3 days later w...

BACKGROUND Initial assessment of dyspepsia often includes noninvasive testing for Helicobacter pylori infection. Commercially available tests vary widely in cost and accuracy. Although there is extensive literature on the cost-effectiveness of H. pylori treatment, there is little information comparing the cost-effectiveness of various currently used, noninvasive testing strategies. METHODS A ...

Delay in initiating appropriate antibiotic treatment in patients with severe nosocomial pneumonia (SNP) is associated with a more unfavorable prognosis,1-6 longer hospital stays, and consequently higher healthcare costs. Moreover, in the context of ventilator-associated pneumonia (VAP), changing inappropriate empiric antibiotic regimens after the causative pathogen has been isolated does not si...

BACKGROUND: Loss of response to anti-TNF agents is a common clinical problem. Dose escalation may be effective for reestablishing in Crohn's disease (CD). AIMS: To perform systematic review assessing the efficacy escalated maintenance therapy CD. METHODS: EMBASE, MEDLINE, Web Science, and CENTRAL databases were searched English language publications through April 25, 2021. Full-text articles ev...

OBJECTIVES To describe the epidemiology, antimicrobial susceptibilities, treatment, and outcomes of intensive care unit (ICU)-acquired Gram-negative bacteremia. METHODS Patients with ICU-acquired Gram-negative bacteremia from 2004 to 2012 were reviewed retrospectively. Independent predictors of mortality were examined using multivariable Cox regression. RESULTS Seventy-eight cases of ICU-ac...

INTRODUCTION Early prediction of the efficacy of treatment in peritonitis complicating peritoneal dialysis (PD) is the best way to reduce morbidity. We studied the prognostic value of the third-day dialysis effluent leukocyte count after antibiotic therapy for prediction of treatment outcomes. MATERIALS AND METHODS Medical records of 31 children on PD, younger than 15 years old, admitted in A...