OBJECTIVES We sought to compare the protective efficacy of enalapril and losartan on lung diffusion in chronic heart failure (CHF). BACKGROUND In CHF, hydrostatic overload causes disruption of the alveolar-capillary membrane and depression of carbon monoxide diffusion (DCO); enalapril improves DCO through mechanisms still undefined; and saline infusion in the pulmonary circulation worsens DCO...

Antihypertensive effects of an angiotensin (Ang) II receptor antagonist, candesartan cilexetil (TCV-116), were compared with those of an angiotensin converting enzyme (ACE) inhibitor, enalapril, in spontaneously hypertensive rats (SHR), 2-kidney, 1-clip hypertensive rats (2K, 1C-HR) and 1-kidney, 1-clip hypertensive rats (1K, 1C-HR). CV-11974, the active form of TCV-116, had no inhibitory activ...

A multicenter, randomized, double-blind trial compared the safety and efficacy of the dihydropyridine isradipine with the angiotensin-converting enzyme (ACE) inhibitor enalapril given twice daily for mild hypertension. 160 patients received either isradipine (starting at 1.25 mg twice daily) or enalapril (starting at 2.5 mg twice daily) for 10 weeks. The dosage was increased if the average sitt...

OBJECTIVE To determine the efficacy of long-term enalapril administration in delaying the onset of congestive heart failure (CHF). DESIGN Placebo-controlled, double-blind, multicenter, randomized trial. ANIMALS 124 dogs with compensated mitral valve regurgitation (MR). PROCEDURES Dogs randomly assigned to receive enalapril or placebo were monitored for the primary endpoint of onset of CHF...

BACKGROUND A natural p300-specific histone acetyltransferase (HAT) inhibitor, curcumin, may have therapeutic potential for heart failure. However, it is unclear whether curcumin exhibits beneficial additive or synergistic effects on conventional therapy with angiotensin-converting enzyme inhibitors (ACEIs). METHODS AND RESULTS Rats were subjected to a sham operation or left coronary artery li...

BACKGROUND Few studies have prospectively and systematically explored the factors that acutely precipitate exacerbation of congestive heart failure (CHF) in patients with left ventricular dysfunction. Knowledge of such factors is important in designing measures to prevent deterioration of clinical status. The objective of this study was to prospectively describe the precipitants associated with...

Endothelial cells are considered to be essential for normal pancreatic β-cell function. The current study attempted to demonstrate the role of insulin receptor substrate-2 (Irs2) in endothelial cells with regard to insulin secretion. Endothelial cell-specific Irs2 knockout (ETIrs2KO) mice exhibited impaired glucose-induced, arginine-induced, and glucagon-induced insulin secretion and showed glu...

De Cavanagh, Elena M. V., Felipe Inserra, León Ferder, and César G. Fraga. Enalapril and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R572–R577, 2000.—The effect of enalapril and captopril on total glutathione content (GSSG 1 GSH) and seleniumdependent glutathione peroxidase (Se-GPx) and glutathione red...

fluvoxamine maleate is a selective serotonin reuptake inhibitor, which is used for the treatment of different types of depressive disorders. in the present study, a stability indicating hplc method was developed and validated for the determination of fluvoxamine maleate. the chromatographic separation was carried out using a nova-pak cn column and a mixture of k2hpo4 50 mm (ph 7.0) and acetonit...