OBJECTIVE Hereditary defects in tooth enamel formation, amelogenesis imperfecta (AI), can be non-syndromic or syndromic phenotype. Integrins are signaling proteins that mediate cell-cell and cell-extracellular matrix communication, and their involvement in tooth development is well known. The purposes of this study were to identify genetic cause of an AI family and molecular pathogenesis underl...

AIM The main purpose of this study was to assess the prevalence and distribution of decayed, missing, and filled teeth (DMFT) and enamel hypoplasia in 12-year old students in junior high school in Iran. MATERIALS AND METHODS This descriptive study was carried out in 2001 on 1,223 12-year old students, which were randomly selected in Yazd and Hadi-Shahr, Iran. A questionnaire was designed to r...

One hundred years ago, histopathology pioneer Bernhard Gottlieb described developmentally disrupted teeth as having “chalky enamel” and spots” that “crumble” easily. He also asked pivotal questions about the pathogenesis of “enamel hypoplasia” remained enigmatic for almost a century. Today, breakthrough pathomechanistic investigations chalky enamel are revealing surprising answers, an allied tr...

Amelogenesis imperfecta (AI) describes a heterogeneous group of inherited dental enamel defects reflecting failure of normal amelogenesis. Ameloblastin (AMBN) is the second most abundant enamel matrix protein expressed during amelogenesis. The pivotal role of AMBN in amelogenesis has been confirmed experimentally using mouse models. However, no AMBN mutations have been associated with human AI....

The aims of this in vitro study were to evaluate the effect of enamel fluorosis on the shear bond strength (SBS) of orthodontic brackets and to determine whether adhesion promoter, Enhance LC, increases the bond strength of brackets to fluorosed enamel. Forty-five (30 fluorosed and 15 non-fluorosed) non-carious fresh human premolar teeth, extracted for orthodontic reasons and without any caries...

RASopathies are syndromes caused by gain-of-function mutations in the Ras signaling pathway. One of these conditions, Costello syndrome (CS), is typically caused by an activating de novo germline mutation in HRAS and is characterized by a wide range of cardiac, musculoskeletal, dermatological and developmental abnormalities. We report that a majority of individuals with CS have hypo-mineralizat...

Amelogenesis imperfecta (AI) is a heterogeneous group of genetic conditions that result in defective dental enamel formation. Amelotin (AMTN) is a secreted protein thought to act as a promoter of matrix mineralization in the final stage of enamel development, and is strongly expressed, almost exclusively, in maturation stage ameloblasts. Amtn overexpression and Amtn knockout mouse models have d...

Like other types of human teeth, the permanent first molar (PFM) has important masticatory function. Since its development and eruption is almost predictable, and the tooth can resist taphonomic conditions, it can form part of possible materials for use in forensic dentistry. The enamel, which forms the coronal outer covering of the tooth, is the hardest tissue of the tooth and is seen with lus...

Background Vitamin D is crucial for mineralized tissue formation and immunological functions. The purpose of this study was to evaluate the association between vitamin D status and dental status in healthy children with vitamin D supplementation in infancy and at 6 years of age. Method Eight-year-old children who had participated in a vitamin D intervention project when they were 6 years old ...

OBJECTIVE The purpose of this study was to assess the prevalence of dental caries, developmental defects of enamel, and related factors in children with clefts. DESIGN This cross-sectional prevalence study used standard dental indices for assessment. SETTING Children underwent a dental examination under standard conditions of seating and lighting in the outpatient department of a dental hos...