New psychoactive substances (NPS) count as substances, which are slightly modified compared to illicit drugs regarding their chemical structure circumvent law. Compared classical such heroin, cocaine, or amphetamine, they show similar effects, however, because of novelty there is few knowledge about side effects toxicity. NPS available different substance classes, among them chiral novel deriva...

A common approach in resolving enantiomers of chiral basic drugs by capillary electrophoresis (CE) is to use cyclodextrins (especially their anionic derivatives) as chiral selector in the acidic buffer (pH ≤ 3) in normal or reversed (carrier) mode. Then, some organic modifiers are added to the buffer solution if the resolution is not satisfactory. In case of cetirizine (CTN), applying the same ...

One of the problems encountered in CE separations of basic compounds is the adsorption of analytes onto the negatively charged capillary wall which could lead to poor repeatability of migration time and peak area. Additionally, separation of enantiomers of chiral of basic drugs is commonly carried out in low pH buffer which contributes to strong ionic interaction of the cationic drug ions with ...

A green chiral lab-on-a-chip cyclodextrin-based microchip electrophoretic method was developed for enantioseparation of baclofen (BCN) and phenylalanine (Phe) enantiomers the first time. All BCN Phe were offline labeled with 4-fluoro-7-nitrobenzofurazan (NBD-F) or fluorescein-5-isothiocyanate (FITC) fluorogenic reagents prior to microfluidic injection in a dynamically coated polymethylmethacryl...

Abstract Novel chiral selectors based on cellulose 2,3- bis (3,5-dimethylphenyl carbamate)-6-( ? -phenylethyl carbamate) were regioselectively synthesized by carbonate aminolysis and isocyanate chemistry. By oxycarbonylation with phenyl chloroformate, carbamoylation 3,5-dimethylphenyl isocyanate, subsequent of the previously introduced reactive moiety at C6 enantiopure ( R )-or S )- -phenylethy...