Endometrial carcinoma is a common malignancy in women, being exceeded in incidence only by that of breast, lung, and colorectal cancers. At present, no serum tumor markers are available for the monitoring of endometrial carcinoma patients, and patients with recurrent disease are detected only following the development of symptoms or abnormalities in imaging assessments. Similarly, no screening ...

Proline-, glutamic acid- and leucine-rich protein-1/modulator of non-genomic activity of estrogen receptor (ER) (PELP1/MNAR) is a novel nuclear receptor (NR) co-activator that plays an essential role in the actions of ER. Emerging findings suggest that PELP1/MNAR is a novel proto-oncogene, whose expression is deregulated in several hormone-respons...

Endometrial cancer is the most common gynecological cancer but there is no economically justified screening method. Although we can detect endometrial cells in the sample using PAP test, many studies show low sensitivity and positive predictive value of PAP test for the diagnosis of endometrial cancer. The goal of this research was to determine significance of PAP test for the diagnostics of en...

A study was performed to clarify the clinicopathological differences between premenopausal endometrial carcinoma, which occurs during the reproductive period, and postmenopausal endometrial carcinoma. We analyzed 76 patients with endometrial carcinoma treated in our department between January 1984 and July 1994. Using classification criteria which included menstrual history and results of endoc...

Endometrial cancer is one of the most common gynaecological cancers in both United States and Russian Federation, rate continues to rise. Although early-stage endometrial associated with a favourable 5-year survival (96%), this patients distant metastases accounts for only 18%. A combination paclitaxel carboplatin standard first-line therapy advanced, recurrent metastatic carcinoma. Pembrolizum...

..................................................................................................................... 7 Introduction ................................................................................................................ 9 Review of the literature ............................................................................................. 10 1. Clinical and histopathol...

We present a 32-year-old patient with solitary brain metastasis of endometrial carcinoma. The single frontal lobe metastasis was determined seven months after surgical staging of endometrial adenocarcinoma. The initial diagnosis was determined by hysterescopic resection of an endometrial polyp. The lesion was only limited to the endometrial polyp and there was no evidence of disease at the path...

 Endometrial adenocarcinoma is uncommon in fewer than 40-year-old people. The first common sign and symptoms are abnormal vaginal bleeding and discharge. Metastasis is occurred in the late stage. Here we present a 31-year-old nullipar woman who was admitted to surgical ward with enlarged right inguinal lymphnode from one month ago. She had no history of previous malignancy, infectious condition...

Tamoxifen is the drug of choice in the treatment of breast cancer.   Recent reports show an increased incidence of endometrial carcinoma in patients taking tamoxifen.   In this article, we report a case of malignant mixed mullerian tumor after tamoxifen use.

© 2009 The Authors. doi: 10.2340/00015555-0718 Journal Compilation © 2009 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, Uterine papillary serous carcinoma (UPSC) was established as a distinct type of endometrial carcinoma by Lauchlan (1) in 1981 and Hendrickson et al. (2) in 1982. UPSC currently constitutes 4% of all endometrial carcinomas and histologically resembles papillary serous adenoca...