O termo sangramento uterino anormal (SUA) é utilizado para definir alterações no proveniente do corpo uterino, isto é, com parâmetros diferentes dos habituais, seja por aumento volume, da frequência ou duração. Consiste em uma patologia, relativamente, comum na vida das mulheres, o que gera inúmeras repercussões negativas cotidiano e convívio social. A fim de classificar as possíveis etiologias...

BACKGROUND Canada has a single-payer, publicly-funded health care system that provides comprehensive health care, and therefore significant disparities in health outcomes are not expected in our population. The objective of this study was to determine if differences exist in endometrial cancer outcomes across regions in Ontario. METHODS This was a population-based study of all endometrial (ut...

BACKGROUND The endometrium becomes receptive to the embryo after sequential actions of estrogen and progesterone. The purpose of this study was to examine the effects of estrogen and progesterone on endometrial hemodynamics and on secretion of vascular endothelial growth factor (VEGF) from endometrial epithelial cells (EEC). METHODS Six early postmenopausal women taking sequential estrogen an...

THE PRESENCE of tissue-specific antigen in various mucins has been demonstrated in a number of studies (Bara et al., 1977; Hillermanns, 1962; Nairn et al., 1962). Antibodies to mucins from alimentary tract can be readily produced and shown by immunofluorescence to localize to endosecretory parts of the epithelial cells. More recently, Gold & Miller (1978) showed that, while common gastrointesti...

Histone deacetylase (HDAC) inhibitors are a new class of anticancer agents that act by inhibiting cancer cell proliferation and inducing apoptosis both in vitro and in vivo. This study examined the anti-tumor effect of apicidin on human endometrial cancer Ishikawa cells in an animal model by inhibiting specific HDAC expression. Nude mice were injected subcutaneously (s.c.) with Ishikawa cells, ...

Rare cells with adult stem cell activity were recently discovered in human endometrium. Endometrial stem/progenitor cell candidates include epithelial, mesenchymal and endothelial cells, and all may contribute to the rapid endometrial regeneration following menstruation, rather than a single candidate. Endometrial mesenchymal stem-like cells (eMSC) are prospectively isolated as CD146+PDGF-Rb+ c...

The secretions of the equine endometrial glands are essential for the survival, growth, and development of the conceptus in early pregnancy, and endometrial gland density is directly related to successful pregnancy outcome. Endometrial biopsy is routinely used to assess the reproductive potential of broodmares. Some previous studies have shown that equine endometrial glands are uniformly distri...

Background: Cancer of the endometrium is the most common gynecologic malignancy in western and industrial countries, and is the second most common in developing countries, therefore it is of special importance. Adenocarcinoma of the endometrium is the most common type of uterine cancer. The prevalence of endometrial cancer in young women under the age of 40 in western country is very low and ab...

Data are limited regarding the occurrence of endometrial cancer after endometrial ablation (EA). A systematic review of the English-language medical literature was performed of cases of endometrial cancer after EA. This review included the present case report involving a 47-year-old woman with a diagnosis of stage IA, grade 1 endometrial adenocarcinoma 5 years after radiofrequency EA. The syste...

BACKGROUND Diagnosis of premalignant endometrial lesions is a major challenge to pathologists. The D-score system is more reproducible than the WHO scheme, however it is not widely available, this study attest a simple custom-made workstation for estimation of the "D-score". MATERIAL AND METHODS Fifteen endometriam with low grade hyperplasia, fifteen proliferative and eight secretory phase en...