Fenitrothion, endosulfan and abamectin are insecticides that affect various organs in humans and animals. The present study was conducted to investigate their cytotoxicity in isolated male rat hepatocytes. The study suggests that incubation of hepatocytes with 10 or 100 microM of each insecticide for 2h significantly decreased the cell viability. Increased leakage percentage of lactate dehydrog...

Humans are usually exposed to several pesticides simultaneously; consequently, combined actions between pesticides themselves or between pesticides and other chemicals need to be addressed in the risk assessment. Many pesticides are efficient activators of pregnane X receptor (PXR) and/or constitutive androstane receptor (CAR), two major nuclear receptors that are also activated by other substr...

Soil salinity and the indiscriminate use of agrochemicals has significantly reduced productivity ‘Chinampas’ agroecosystem in Mexico City. Crop improvement under these stressful conditions may be achieved by soil bioremediation. In this study, we checked effects organochlorine pesticide endosulfan bioremediation with Penicillium crustosum or a citric waste on growth Phaseolus leptostachyus plan...

BACKGROUND Endosulfan has been used for over 50 years. Although most analogs have been discontinued, endosulfan has less environmental persistence. Nevertheless, pressure groups are lobbying for a worldwide ban. The reasons are: possible rodent male reproductive toxicity, other endocrine effects and cancer; human epidemiology, and exposure studies; residues appearing in remote areas of the worl...

Humans are usually exposed to several pesticides simultaneously; consequently, combined actions between pesticides themselves or between pesticides and other chemicals need to be addressed in the risk assessment. Many pesticides are efficient activators of pregnane X receptor (PXR) and/or constitutive androstane receptor (CAR), two major nuclear receptors that are also activated by other substr...

the effects of pesticide endosulfan (an organochlorine compound), on the ovaries of bluegill fish (lepomis macrochirus) were studied. exposures for 24 hs with histological preparations at 25% (0.25 î¼g/l), 75 % (0.75 î¼g/l), and 100 % (1 î¼g/l) sub lethal concentrations were examined. the control contained an abundance of the different stages of oocytes (oocytes i, ii, iii, and iv) and had an i...

In order to elucidate the importance of food-borne chemical contamination in fish, cytological and ultrastructural alterations in hepatocytes and enterocytes of common carp Cyprinus carpio L. exposed for 5 wk to 0.5 microgram endosulfan (6,7,8,9,10,10-hexachloro-1,5,5a,6,9a-hexahydro-6,9-methano-2,4,3-benzo- dioxyanthiepin-3-oxide) kg-1 food dry weight, equivalent to an ultra-low dosis of 15 ng...