Background and Objective: Vascular endothelial growth factor (VEGF) and its receptors (VEGF-R1 and R2) are major regulators of angiogenesis. This study was designed to assess serum levels of VEGF and VEGF-R1 and their prognostic significance in newly diagnosed childhood acute leukemia. Materials and Methods: For this purpose, VEGF and VEGF-R1 were determined using enzyme linked immuno-sorba...

The complex and hierarchical vascular network of arteries, veins, capillaries features considerable endothelial heterogeneity, yet the regulatory pathways directing arteriovenous specification, differentiation identity are still not fully understood. Recent advances in analysis endothelial-specific gene elements, single cell RNA sequencing (scRNA-seq) lineage tracing has both emphasized importa...

The article contains the analysis of results concerning investigation adipocytokines content and endothelial dysfunction in 97 patients with irritable bowel syndrome associated obesity. blood serum was examined for (leptin, adiponectin, resistin), stable nitrogen monoxide metabolites (nitrites/nitrates), endothelin-1, intercellular adhesion molecule 1 (ICAM-1), number circulating cells (CEC). P...

Objective(s): Herbal medicines are promising cancer preventive candidates. It has been shown that Punica granatum L. could inhibit angiogenesis and tumor invasion. In this study, we investigated whether the anti-angiogenic effect of pomegranate peel extract (PPE) is partly attributable to Peroxisome proliferator-activated receptors (PPARs) activation in the Human Umbilical Vein Endothelial Cell...

background: mesenchymal stem cells (mscs) are multipotent cells, capable of differentiating into different cell lines.they can sense their surrounding biochemical and biophysical factors, which play major roles in their differentiation toward different phenotypes. therefore, the exposure of these cells to endothelial growth factor (vegf) as well as hemodynamic biomechanical forces, which act on...

various polymorphisms on endothelial nitric oxide synthase (enos) gene cause reduced production of no, the endothelial relaxing factor, and may accelerate the process of atherosclerosis. the study designed to investigate the frequency of t-786c polymorphism of the enos gene in patients suffering from coronary artery disease (cad) in north-west of iran. one hundred twenty subjects including 60 p...

background :chronic obstructive pulmonary disease (copd) is a third leading cause of death.   methods : in this case control study, we prepared 5 cc bloods from the antecubital vein of 100 copd patients and 40 healthy individuals as control group. vascular endothelial growth factor (vegf) expression protein level was measured by elisa in both groups.   results : we found that concentration of v...

objective(s):many studies have reported that tea consumption decreases cardiovascular risk, but the mechanisms remain unclear. green tea is known to have potent antioxidant and free radical scavengingactivities. this study aimed to investigate whether green tea extract (gte) can protect endothelial progenitors cells (epcs) against oxidative stress through antioxidant mechanisms. materials and m...

Abstract The Cholinergic Anti-inflammatory Pathway (CAP) is a neurophysiological mechanism that regulates the immune system. Studies show CAP inhibits inflammation by suppressing cytokine synthesis via release of acetylcholine in heart, lungs and gastrointestinal tract. Upon release, interacts with α7 nicotinic receptors (α7nAChR), down-regulate pro-inflammatory prevent tissue damage inflammati...