Migraine shows strong familial aggregation. However, the number of genes involved in the disorder is unknown and not identified. Nitric oxide is involved in the central processing of pain stimuli and plays an important role in the regulation of basal or stimulated vasodilation. Nitric oxide synthase, which controls the synthesis of nitric oxide, could possibly be a cause, or candidate gene, in ...

The advantages of exercise training in patients with atherosclerotic coronary artery disease are numerous and include the modification of traditional risk factors, improvement in myocardial and peripheral perfusion, enhancement of exercise tolerance, and reduction of cardiovascular morbidity and mortality.1 These salutary effects are thought to result from improvements in endothelial function a...

Krüppel-like Factor 2 (KLF2) is a 38-kDa transcription factor that is highly expressed in the vascular endothelium. The enormous attention that KLF2 has received in recent years is well deserved, because experimental evidence has shown that it is a vital protein that, via transcriptional and nontranscriptional targets, mediates a host of endothelial functions.1 These include inhibition of vascu...

Background: Reduced endothelial nitric oxide bioavailability, a hallmark of endothelial dysfunction, is commonly encountered in cardiovascular diseases. Intermittent fasting reduces serum markers of oxidative stress, while nitric oxide levels may rise. Whether this translates into persistent improvements in endothelial function is unknown. The aim of the study was to address the effects of inte...