purpose: to evaluate the corneal endothelial cell density and polymegathism one year after laser assisted keratomileusis using mitomycin c. methods: one hundred and three eyes from 52 patients who underwent laser assisted sub-epithelial keratomileusis using mitomycin c 0.02% for 30 seconds entered this study. corneal endothelial cells were evaluated using specular microscopy before and one year...

The complex and hierarchical vascular network of arteries, veins, capillaries features considerable endothelial heterogeneity, yet the regulatory pathways directing arteriovenous specification, differentiation identity are still not fully understood. Recent advances in analysis endothelial-specific gene elements, single cell RNA sequencing (scRNA-seq) lineage tracing has both emphasized importa...

Adrenal hemangiomas are rare benign tumors arising from the endothelial cells lining blood vessels, which made up of angioblastic cells. They usually identified incidentally on radiographic imaging and post-operative histopathology is definitive diagnosis. Computed tomography magnetic resonance help in detection silent adrenal lesions. We present a case outline diagnostic work-up treatment dete...

background: marrow-derived mesenchymal stem cells (mscs) have been heralded as a source of great promise for the regeneration of the infarcted heart. there are no clear data as to whether or not in vitro differentiation of mscs into major myocardial cells can increase the beneficial effects of mscs. the aim of this study was to address this issue. methods: to induce mscs to transdifferentiate i...

endothelial cells present in brain are unique and differ from other peripheral tissues in a number of ways, which ensures specific brain endothelial barrier properties. endothelial dysfunction is the earliest event in the initiation of vascular damage caused by inflammation. various micrornas (mirna) have been discovered in different cellular components of the blood bran barrier (bbb). mirnas a...

Aldosterone is traditionally viewed as a hormone regulating electrolyte and blood pressure homeostasis. Recent studies suggest that Aldo can cause microvascular damage, oxidative stress and endothelial dysfunction. However, its exact cellular mechanisms remain obscure. This study was undertaken to examine the effect of Aldo on superoxide production in human umbilical artery endothelial cel...

Abstract The endothelial-to-mesenchymal transition (EndMT) is a critical process that occurs during the development of outflow tract (OFT). Malformations OFT can lead to occurrence conotruncal defect (CTD). SOX7 duplication has been reported in patients with congenital CTD, but its specific role remains poorly understood. To decipher this, histological analysis showed SRY-related HMG-box 7 (SOX...