Since the classical article of M. B. Schmidt meningeal tumors have been generally considered to arise from clusters of arachnoidal cells, and controversy concerning them has been largely terminological. Many have objected to the common term dural endothelioma on the grounds that the tumors arise from the arachnoidal membrane and that the neoplastic cells are not endothelial. Mallory, followed b...

The possibility of using genes as medicines to treat brain diseases is currently limited by the lack of safe and efficacious delivery systems able to cross the blood-brain barrier, thus resulting in a failure to reach the brain after intravenous administration. On the basis that iron can effectively reach the brain by using transferrin receptors for crossing the blood-brain barrier, we propose ...

Immunotoxins containing recombinant human-derived single-chain fragment variable (scFv) reagents (83 and 40) against CTLA-4 (CD152) linked to saporin, a ribosome-inactivating protein, were prepared and tested on CD3/CD28-activated T lymphocytes, MLRs, CTLA-4-positive cell lines, and hemopoietic precursors. Immunotoxins induced apoptosis in activated T lymphocytes and were able to specifically i...

We used in vitro and in vivo approaches to examine whether tumor necrosis factor-alpha (TNF-alpha) and oncostatin M (OSM), cytokines that bind to distinct classes of receptors, differentially regulate expression of P- and E-selectin in murine and primate endothelial cells. In human umbilical vein endothelial cells, TNF-alpha rapidly increased mRNA for E-selectin but not P-selectin. OSM elicited...

We used in vitro and in vivo approaches to examine whether tumor necrosis factor-a (TNF-a) and oncostatin M (OSM), cytokines that bind to distinct classes of receptors, differentially regulate expression of Pand E-selectin in murine and primate endothelial cells. In human umbilical vein endothelial cells, TNF-a rapidly increased mRNA for E-selectin but not P-selectin. OSM elicited little or no ...

It is known that paralleling the growth of fowls antibody-like factors against many bacteria and foreign cells appear regularly in their blood.' 5, 6 Cancer-inducing viruses are also affected by similar factors.7 The viruses of the Rous and Fuginami sarcoma and of the Mill Hill 2 endothelioma are strongly neutralized by the serum of adult fowls, but the Rous virus, the only one studied in this ...

The integrin very late antigen, (VLA-4) alpha 4 beta 1 and its counter receptor vascular cell adhesion molecule 1 (VCAM-1) are involved in B cell maturation and pre-B cell attachment to bone marrow stroma cells. We have analyzed whether heat-stable antigen (HSA), a marker for immature leukocytes, is involved in such cell adhesion phenomena. HSA is a glycolipid-anchored, highly glycosylated surf...

Lymphoid tumors of the chicken have been shown to be readily transplantable by the use of viable cells. Pentimalli (29) and Olson (25, 27) have described the isolation of such strains from what was thought (28) were rare cases of neoplasia, but which had all the characteristics of the condition designated by Feldman and Olson (9) as lymphocytoma. Burmester and Prickett (7) reported the developm...

The need for uncovering molecular mechanisms in endothelial cell biology has tremendously increased in the last decades as it became more and more clear that the endothelium is an important target in nearly all diseases and treatments (drug delivery) and plays a central role in regeneration processes. One of the critical methods generally applied in cell biology research to uncover structural a...

Genetic experiments (loss-of-function and gain-of-function) have established the role of Angiopoietin/Tie ligand/receptor tyrosine kinase system as a regulator of vessel maturation and quiescence. Angiopoietin-2 (Ang-2) acts on Tie2-expressing resting endothelial cells as an antagonistic ligand to negatively interfere with the vessel stabilizing effects of constitutive Ang-1/Tie-2 signaling. An...