Garcinia mangostana (GM) pericarp is an herbal medicine in the Thailand National Essential Drug List. GM and its major active constituent α-mangostin (MGS) exhibit several pharmacological properties, including anti-oxidative activity. Ulcerative colitis (UC) consequence of prolonged oxidative stress inflammation large intestine can result in extraintestinal manifestations (EIM) other ...

Soils are obviously inconstant and their properties changing across land use types. Essential soil physico-chemical assets impact the performance of and, therefore, information on property is important. The objective study was to determine effects different systems in Wolaita zone, southern Ethiopia. Soil samples were collected from three uses, enset ( Ensete ventricosum ), tef Eragrostis (Zucc...

INTRODUCTION While the literature is replete with studies of the toxic potency of pentachlorophenol (PCP), site-specific criteria for native aquatic species that can be used in ecological risk assessments has been lacking and application of toxicity information for non-native species is controversial. MATERIALS AND METHODS In the present study, acute and chronic toxicities of PCP to six aquat...

Amino acids exert nephroprotective effects in various forms of acute renal injury depending on their renal hemodynamic effects. The present study was designed to elucidate and compare the role of non hemodynamic mechanisms in protective actions afforded by glycine and L-arginine against cisplatin (CDDP)-induced nephrotoxicity using rat renal cortical slices (RCS). We have investigated the possi...

INTRODUCTION Contrast-induced nephropathy is one of the main causes of acute kidney injury and increased hospital-acquired morbidity and mortality. The use of sodium bicarbonate for nephroprotection has emerged as a preventative strategy; however, its efficacy is controversial compared to other strategies, such as hydration using 0.9% saline solution. OBJECTIVE To compare the effectiveness of...

INTRODUCTION The kidneys play an essential role in PRRT. The infusion of amino acids could reduce uptake in the kidney of radiolabelled peptides. The purpose of this study was to determine the extent of kidney damage post PRRT. MATERIAL AND METHODS 53 patients, with disseminated neuroendocrine tumours (NET), received 3-5 cycles of up to a maximum 7.4 GBq/m2 calculated dose of 90Y-DOTATATE (n ...

In the past decade, research has advanced our understanding how endothelin contributes to proteinuria and glomerulosclerosis. Data from pre-clinical and clinical studies now provide evidence that proteinuric diseases such as focal segmental glomerulosclerosis and diabetic nephropathy as well as hypertension nephropathy are sensitive to treatment with endothelin receptor antagonists (ERAs). Like...

ACE inhibition protects kidney function, but ACE insertion/deletion (I/D) polymorphism affects renal prognosis in type 1 diabetic patients. ACE genotype may influence the renal benefits of ACE inhibition. We studied the impact of ACE I/D polymorphism on the renal hemodynamic changes induced by ACE inhibition in type 1 diabetes. We studied renal hemodynamics (glomerular filtration rate [GFR], ef...