Acetylcholinesterase enzyme (AChE) is the that catalyzes hydrolysis of neurotransmitter acetylcholine to choline. Inhibitors this (AChE-i) are used treat Alzheimer's, a neurodegenerative disease. Due side effects drugs used, there has been an increased interest in investigating inhibitory potentials natural products which presumed have fewer effects. For purpose, highland honey, chestnut royal ...

The ecto-5′-nucleotidase CD73 is involved in the production of immunosuppressive adenosine tumoral microenvironment and recently became a validated target immuno-oncology. To avoid formation CD73-produced adenosine, several series potential inhibitors enzyme based on triazole scaffold were synthetized evaluated recombinant purified hCD73 cell-based assays.