BACKGROUND The goal of this study was to assess whether angiotensin-converting enzyme (ACE) activity is related to muscle function (strength, power and velocity), as well as to assess if ACE inhibitors (ACEIs) and other angiotensin system blocking medications (ASBMs) influence muscle performance in elderly women. SUBJECTS AND METHODS Ninety-five community-dwelling elderly women took part in t...

INTRODUCTION A number of the recently published papers have suggested that high mortality among women with acute coronary syndromes might be related to suboptimal pharmacological treatment, namely to the lower rate of administration of antiplatelet agents, statins, β-blockers, and angiotensin-converting enzyme inhibitors (ACEIs). OBJECTIVES The aim of the study was to compare pharmacotherapy ...

Diabetic nephropathy (DN) is a serious complication of both type 1 and type 2 diabetes mellitus. The disease is now the most common cause of end-stage kidney disease (ESKD) in developed countries, and both the incidence and prevalence of diabetes mellitus is increasing worldwide. Current treatments are directed at controlling hyperglycemia and hypertension, as well as blockade of the renin angi...

Background: The use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) is controversial for treating COVID-19 patients. We aimed to estimate pooled risks mortality, disease severity, and hospitalization associated with ACEI/ARB stratify them by country clusters. Methods: conducted a search in various databases through 4 July 2020 then applied random-effe...

Background: Angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) may be associated with higher susceptibility of COVID-19 infection and adverse outcomes. We compared ACEI/ARB use positivity in a case–control design, severity positive patients. Methods: Consecutive patients who attended Hong Kong's public hospitals outpatient clinics between 1 January 28 July ...

INTRODUCTION Heart failure (HF) is a common and potentially fatal condition. Cardiovascular research has focused on medical therapy for HF. Theoretical modelling could enable simulation and evaluation of the effectiveness of medications. Furthermore, the models could also help predict patients' cardiac response to the treatment which will be valuable for clinical decision-making. METHODS This...

BACKGROUND Calcium accumulation in the aortic valve is a hallmark of aortic sclerosis and aortic stenosis. Because lipoproteins, angiotensin-converting enzyme, and angiotensin II colocalize with calcium in aortic valve lesions, we hypothesized an association between angiotensin-converting enzyme inhibitor (ACEI) use and lowered aortic valve calcium (AVC) accumulation, as measured by electron be...

Atrial fibrillation (AF) is the most common sustained arrhythmia associated with increased morbidity and mortality. Efficacy and safety of currently employed antiarrhythmic drugs (AADs) continue to be less optimal in AF. Development of newer AADs has recently been made possible through a greater understanding of electro-pathophysiology of AF. Highly specific drugs acting on atria are currently ...

Introduction Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are recommended as first-line therapy for hypertension in patients with chronic kidney disease (CKD). The relevant evidence extends from background studies showing that blood pressure (BP) reduction with agents that block the renin–angiotensin–aldosterone system (RAAS) yielded greater structur...

Angiotensin II type 1 receptor antagonists [ARBs (angiotensin receptor blockers)] are indicated for BP (blood pressure)-lowering, renal protection and cardioprotection in patients unable to tolerate ACEIs (angiotensin-converting enzyme inhibitors). A recent meta-analysis revealed an association between ARBs and tumour development, possibly due to enhancement of angiogenesis. However, published ...