Epigenetic mechanisms offer explanations for how environmental exposures at critical life periods may affect human biological and disease phenotypes. Incorporation of epigenetic approaches into research on health consequences of societal transitions may increase understanding of the complex biobehavioral factors influencing changing populations. Description of present and planned genetic epidem...

T HE high morbidity and mortality from atherosclerotic and hypertensive cardiovascular diseases in the United States emphasize the need for their prevention and control and have led to epidemiologic research in these areas in this and other countries. In the application of epidemiologic principles to the study of atherosclerosis and high blood pressure, various criteria, methods and technics ar...

Several maternal and pregnancy characteristics have been associated with an increased risk of preeclampsia in epidemiological studies. This review discusses metabolic risk factors in particular and their interaction with other maternal and/or pregnancy characteristics. Examples of research studies that have used data from women with specific characteristics or explored the interaction between r...

OBJECTIVE To develop a physical activity questionnaire aimed at Brazilian adolescents and to assess its validity and reproducibility. METHODS A total of 94 adolescents (30 males and 64 females) aged 11-16 years were included in the study, which was conducted in 2004. The questionnaire comprised 17 questions on habitual physical activity in the last 12 months (15 questions on sports and physic...

Knowledge regarding the physiological role and dietary requirements of vitamin D has dramatically expanded over the past several decades. The "new" vitamin D is not only a mediator of calcium homeostasis, it also has important immunomodulatory, antimicrobial, and antiproliferative actions. In spite of the interest in vitamin D as a mediator in many chronic diseases of adulthood such as cancer a...

This analysis presents a detailed defense of my epidemiologic research in the May 17, 2003 British Medical Journal that found no significant relationship between environmental tobacco smoke (ETS) and tobacco-related mortality. In order to defend the honesty and scientific integrity of my research, I have identified and addressed in a detailed manner several unethical and erroneous attacks on th...

BACKGROUND Snakebite has recently been declared a global public health emergency. Empirical data showing the true burden of snakebite is lacking. Treatment with specific antivenoms is considered the only cure. However, several factors have led to an ongoing antivenom crisis. This study offers recommendations concerning the improvement of antivenom access and control, by providing an overview of...

The aim of this study was to verify the prevalence of physical inactivity and associated factors among adolescents commuting to school. This was an epidemiological study based on secondary data from a sample of 4,207 adolescents (14-19 years). Data were collected through a previously validated questionnaire (GSHS-WHO). Adolescents were classified as "inactive in commuting" when they reported no...

INTRODUCTION Recent epidemiologic research studies in rural Alaska have examined risk factors for infectious diseases collected at the household level. Examples include the health effects of in-home piped water and household air quality. Because the exposure is measured at the household level, it is necessary to determine if participants remained in the same house throughout the course of follo...