BACKGROUND The postnatal development of the epididymis is a complex process that results in a highly differentiated epithelium, divided into several segments. Recent studies indicate a role for RNA interference (RNAi) in the development of the epididymis, however, the actual requirement for RNAi has remained elusive. Here, we present the first evidence of a direct need for RNAi in the different...

Testosterone and 5 alpha-dihydrotestosterone (DHT) concentrations in tissue and body fluid were determined in adult male rats to investigate the mode of androgen distribution. The highest concentration of androgen (testosterone + DHT) and the smallest ratio of DHT/testosterone were observed in the intratesticular tissue fluid. The androgen concentration in testicular vein blood was much higher ...

Solid epididymal masses can be broadly classified into three categories: inflammatory mass, benign neoplasm, and malignant neoplasm. Examples of inflammatory processes include infectious epididymitis, fibrosis, sperm granuloma, and autoimmune disease. Benign neoplasms include adenomatoid tumor or leiomyoma. Malignant neoplasms include adenocarcinoma, embryonic rhabdomyosarcoma, and seminoma. Wh...

Androgen binding protein (ABP) has been shown to be secreted by Sertoli cells and to be actively taken up by the efferent ducts and proximal caput epididymidis and, yet, to be present at high concentrations in epididymal fluids. In the present study, ABP was immunolocalized by light microscopy in epithelial cells of the efferent ducts and epididymis of adult rats and during postnatal developmen...

BACKGROUND Epididymal anomalies and patent processus vaginalis are frequently found in boys with cryptorchidism or hydrocele. We conducted this study to evaluate the association between epididymal anomalies and testicular location or patent processus vaginalis in boys with undescended testis or hydrocele. METHODS Children undergoing surgery with undescended testis (group A, 136 boys and 162 t...

INTRODUCTION Acute epididymo-orchitis (AEO) is an acute inflammatory disease of the epididymis and ipsilateral testis. Treatment should be started immediately after diagnosis and includes antibiotics, analgesics, and, if necessary, surgery. MATERIALS AND METHODS After AEO diagnosis, patients were treated conservatively with analgesics and antibiotics. If no clinical improvement was observed w...

BACKGROUND Precious fruits like jambul are neglected and wasted while environmental pollutants like lead intake remain overlooked. OBJECTIVE The aim of this study was to investigate the effects of the Jambul pulp extract on lead detrimental effects in pseudostratified epithelium and the stereocilia of mice epididymis and vas deferens. MATERIALS AND METHODS Thirty young males mice (Mus muscu...

Background: The main aim of the present study was to evaluate the ameliorative effect of curcumin on aflatoxin-induced changes in caput and cauda epididymis of mice. Materials and Methods: Aflatoxin was obtained by growing Aspergillus parasiticus in sucrose magnesium sulphate potassium nitrate yeast extract (SMKY) liquid medium. Pure curcumin (97% purity) was purchased from Hi-Media Laboratorie...

OBJECTIVES To assess the incidence of anatomical anomalies in patients with retractile testis. MATERIALS AND METHODS We studied prospectively 20 patients (28 testes) with truly retractile testis and compared them with 25 human fetuses (50 testes) with testis in scrotal position. We analyzed the relations among the testis, epididymis and patency of the processus vaginalis (PV). To analyze the ...