In an era where humanity is reinstating its lost hope and expectation on natural products, green tea occupies quite a position for what it has proven to be, in endeavors human welfare health. Epigallocatechin-3-gallate (EGCG) the key vast biological activities of tea. Green no longer backdrop; emerged as most viral, trending bioactive molecule when comes health benefits beings. This review focu...

The broth microdilution checkerboard and time-kill techniques were used to investigate the combination effects of (-)-epigallocatechin gallate (EGCg) and p-Iactams against various p-Iactamase-producing clinical isolates. Penicillin in combination with 12.5 ~g/ml EGCg showed the potent synergy against the penicillinase-producing S. aureus (21 strains) and restored the antibacterial activity of p...

Safely eradicating prions, amyloids and preamyloid oligomers may ameliorate several fatal neurodegenerative disorders. Yet whether small-molecule drugs can directly antagonize the entire spectrum of distinct amyloid structures or 'strains' that underlie distinct disease states is unclear. Here, we investigated this issue using the yeast prion protein Sup35. We have established how epigallocatec...

In our efforts to develop new approaches to treat and prevent human vascular diseases, we report herein our results on the proliferation and migration of human smooth muscles cells (SMCs) and endothelial cells (ECs) using epigallocatechin-3-gallate conjugated gold nanoparticles (EGCg-AuNPs) as possible alternatives to drug coated stents. Detailed in vitro stability studies of EGCg-AuNPs in vari...

BACKGROUND Human glioblastoma is a deadly brain cancer that continues to defy all current therapeutic strategies. The authors induced apoptosis in human glioblastoma T98G and U87MG cells after treatment with apigenin, (-)-epigallocatechin, (-)-epigallocatechin-3-gallate (EGCG), and genistein, which did not induce apoptosis in human normal astrocytes. METHODS Induction of apoptosis was examine...

Here we have investigated the inhibitory properties of green tea catechins on the Plasmodium falciparum hexose transporter (PfHT), the Babesia bovis hexose transporter 1 (BboHT1) and the mammalian facilitative glucose transporters, GLUT1 and GLUT5, expressed in Xenopus laevis oocytes. (-)-Epicatechin-gallate (ECG) and (-)-epigallocatechin-gallate (EGCG) inhibited D-glucose transport by GLUT1 an...

BACKGROUND Myocardial ischemia/reperfusion injury (MIRI) usually induces serious health problems. OBJECTIVES This study attempted to explore protective effects of (-)-epigallocatechin-3-gallate (EGCG) on MIRI and the associated mechanism. MATERIAL AND METHODS Ischemia/reperfusion an isolated rat heart (I/R model) model were used in this study. infarction was measured with staining 2,3,5-triphen...

Objectives: Macrophages are determinant cells for atherosclerotic lesion formation. The objectives of this study were to incorporate macrophage target ligands on the surface of biocompatible and biodegradable epigallocatechin gallate (EGCG)-loaded nanoparticles (Enano), to evaluate their target specificity to macrophages and antiatherogenic effects in vitro and in vivo. Method: The target speci...

The single crystal of (-)-gallocatechin-3-O-gallate (GCg) was prepared using a solution containing an equimolecular amount of GCg and (-)-epigallocatechin-3-O-gallate (EGCg) in water. The crystal structure of GCg determined by X-ray crystallographic analysis was monoclinic with the space group P2(1) at 223 K. Offset pi-pi interactions formed between the A and A rings, B and B rings, and gallate...

Bladder cancer is the fourth most common cancer in males and the ninth most common in females. However, despite the numerous advances made in the past few decades, the prognosis of patients with bladder cancer remains poor. Metastasis is one of the major causes of mortality in bladder cancer patients. Therefore, the inhibition of metastasis is one...