Women with epilepsy face unique challenges, some of which arise from the interaction between epilepsy and endocrine hormones. Epilepsy and endocrine hormones reciprocally influence one another such that hormonal changes impact epilepsy and epilepsy impacts hormonal functioning. In this article, the effect of that interaction on the lifelong health of epileptic women is examined. Fluctuations in...

PURPOSE The objective of this study was to explore the efficacy of low dose of oxcarbazepine (OXC) in adult patients with newly diagnosed partial epilepsy in an actual clinical setting. The associated factors influencing the poor control of seizures were also evaluated. METHODS The epilepsy database (2010-2014) from the Epilepsy Clinic of West China Hospital was retrospectively reviewed. RE...

AIMS In temporal lobe epilepsy (TLE) due to hippocampal sclerosis reorganisation in the memory encoding network has been consistently described. Distinct areas of reorganisation have been shown to be efficient when associated with successful subsequent memory formation or inefficient when not associated with successful subsequent memory. We investigated the effect of clinical parameters that mo...

Temporal lobe epilepsy is often medically refractory and new targets for intervention are needed. We used a mouse model of temporal lobe epilepsy, on-line seizure detection, and responsive optogenetic intervention to investigate the potential for cerebellar control of spontaneous temporal lobe seizures. Cerebellar targeted intervention inhibited spontaneous temporal lobe seizures during the chr...

Intractable focal epilepsy is a devastating disorder with profound effects on cognition and quality of life. Epilepsy surgery can lead to seizure freedom in patients with focal epilepsy; however, sometimes it fails due to an incomplete delineation of the epileptogenic zone. Brain networks in epilepsy can be studied with resting-state functional connectivity analysis, yet previous investigations...

Vagus nerve stimulation (VNS) provides palliation of seizure reduction for patients with medically refractory epilepsy. VNS is indicated for symptomatic localization-related epilepsy with multiple and bilateral independent foci, symptomatic generalized epilepsy with diffuse epileptogenic abnormalities, refractory idiopathic generalized epilepsy, failed intracranial epilepsy surgery, and other s...

introduction: seizures are symptoms associated with abnormal electrical activity in electroencephalogram (eeg). the present study was designed to determine the effect of absence seizure on heart rate (hr) changes in electrocardiogram (ecg). methods: hr alterations were recorded simultaneous with spike and wave discharges (swd) by eeg in 6 wag/rij rats as a well characterized and validated genet...

BACKGROUND Epilepsy is a common neurologic complication of tuberous sclerosis complex (TSC) and it is often refractory to treatment. Therefore, treating physicians are often reluctant to discontinue antiepileptic drugs (AEDs) in individuals with TSC who have attained seizure remission. To our knowledge, seizure remission and AED discontinuation in children with TSC has not been studied. OBJEC...

Received: November 6, 2015; Accepted: August 26, 2016; Published online: October 28, 2016

Epilepsy is a neurological disorder characterized by epileptic seizures resulting from neuronal hyperexcitability, which may be related to failures in Na,K-ATPase activity and oxidative stress participation. We conducted this study investigate the impact of antioxidant therapy on stress, activity, seizure factors, mortality rodent seizure/epilepsy models induced pentylenetetrazol (PTZ), pilocar...