Candida glabrata previously considred as a nonpa-thogenic commensal microorganism of human mucosal tissues, is now mentioned as the second or third cause of nosocomial candidiasis and have significantly increased recently due to immuno-suppressive therapies (1). Among the Candida species, C. glabrata is inherently resistant to azole anti-fungal agents. The mutations occurred in several ergoster...

To provide insights into the structure-function relationships of oxidosqualene-lanosterol cyclase (ERG7) from Saccharomyces cerevisiae, the Phe699 was exchanged against hydrophilic polar uncharged residues Ser, Thr, Cys, Gln, and Tyr to characterize its product profile and functional role in ERG7 activity. Among the substitutions, only the ERG7F699T mutant produced novel protosta-13(17),24-dien...