The efficacy of radiotherapy, one major treatment modality for esophageal squamous cell carcinoma (ESCC) is severely attenuated by radioresistance. Epithelial-to-mesenchymal transition (EMT) is a cellular process that determines therapy response and tumor progression. However, whether EMT is induced by ionizing radiation and involved in tumor radioresistance has been less studied in ESCC. Using...

AIM The aim of this study was to evaluate the effects of radiotherapy plus concurrent weekly cisplatin chemotherapy on the postoperative recurrence of mediastinal lymph node metastases in esophageal cancer patients. METHODS Ninety-eight patients were randomly enrolled to receive either three-dimensional conformal radiotherapy alone (group A) or concurrent chemoradiotherapy (group B). A radiat...

PURPOSE This systematic analysis was conducted to evaluate the efficacy and safety of pemetrexed-based chemoradiotherapy in treating patients with locally advanced or metastatic esophageal cancer. METHODS Clinical studies evaluating the efficacy and safety of pemetrexed based regimens on response and safety for relevant patients were identified using a predefined search strategy. Pooled respo...

Background: We analyzed local regional recurrence patterns of thoracic esophageal carcinoma after three-field lymph node dissection (3-FLD) with and without postoperative radiotherapy, assessed the radiation value for control. Methods: The study reviewed 239 recurrences squamous cell 3-FLD from 2010 to 2018 in our hospital, retrospectively, compared between sur...

Objective Approximately half of patients with cancer have comorbidities, such as adjustment disorder, major depressive and delirium. Radiotherapy can cause psychological problems, e.g., the fear treatment its side effects, anxiety, depression, social isolation. Health-related quality life (QoL) must be determined to evaluate effectiveness treatment. We analyzed clinical, psychological, sociodem...

In 2001, 10,677 people died of esophageal cancer in Japan, 9,026 were men and 1,651 women–demonstrating a male-to-female ratio of 5.5. The number of esophageal cancer deaths have been increasing, correlated with the aging of Japan’s population. During the last two decades, the number of esophageal cancer deaths for men has increased by two-fold, and that for women 1.3-fold. The overall death ra...

Esophageal carcinoma is a high-incidence malignant tumor in China, ranking sixth and fourth highest morbidity mortality, respectively. Radiotherapy plays an important role the comprehensive treatment of esophageal carcinoma. Standardized diagnosis based on suggestions multidisciplinary team (MDT) form its foundation. For operable carcinoma, surgery after neoadjuvant chemoradiotherapy standard t...