Accepted May 17, 2012 The present research work deals with the development of a time delayed chronotherapeutic formulation of felodipine (FD) aimed at rapid drug release after a desired lag time in the management of hypertension. The developed system comprises a drug core embedded within a swellable layer and coated with an insoluble, water permeable polymeric system. FD cyclodextrin complex wa...

The present research work deals with the development of a time delayed chronotherapeutic formulation of felodipine (FD) aimed at rapid drug release after a desired lag time in the management of hypertension. The developed system comprises a drug core embedded within a swellable layer and coated with an insoluble, water permeable polymeric system. FD cyclodextrin complex was used as an active co...

Thin mesoporous titania films prepared by surfactant templating feature some of the highest light conversion efficiencies per thickness ratios as anodes in dye-sensitized solar cells (DSCs). However, the fabrication of thicker films required for sufficient light absorption is very challenging using this approach, often resulting in cracking and delamination of the films. Here we present a simpl...

This study was performed to achieve sustained-release Ibuprofen matrix tablets with a zero-order release kinetic while most of the previous formulations have shown Higuchi release kinetic. Considering the results from previous studies, ethyl cellulose, Carbopol 934P, Carbopol 974P, and Pemulen TR-1 were used at different amounts for preparation of the tablets by direct compression. The release ...

E-mail: [email protected] The objectives of the present investigation were: (1) to elucidate the effect of formulation variables e.g., amount of Eudragit RS 100, concentration of Tween 80 and agitation speed on in-vitro release profiles of indomethacin from multiparticulates system, formulated with the combination of ethyl cellulose and Eudragit RS 100 by using a novel quasi emulsion solve...

Transdermal patches were developed for a low oral bioavailable drug, lacidipine (LCDP) employing ethyl cellulose/Eudragit RL100 and polyvinyl pyrollidone (PVP) as polymeric matrices. The effect of binary mixtures of polymers on physicochemical properties such as thickness, moisture absorption and moisture content; in vitro release, ex vivo permeation and mechanical properties was evaluated. Ex ...

PURPOSE To develop and validate a method to prepare clarithromycin (CLM) microcapsules to mask the bitter taste and provide effective treatment, and evaluate the quality of microcapsules in detail, especially the in vitro and in vivo pharmacokinetics behavior. METHODS CLM microcapsules were prepared using ethyl cellulose as matrix material by an emulsion solvent diffusion method. The physicoc...

Nonoxidative alcohol metabolism catalyzed by fatty acid ethyl ester (FAEE) synthases may contribute to extrahepatic injury resulting from alcohol abuse. Unlike rabbit myocardial FAEE synthase, that from human heart has a satellite minor synthase (I) eluting from DEAE cellulose at a conductivity of 5 mS. Synthase I was purified 1,118-fold to homogeneity by sequential gel permeation, hydrophobic ...

The aim of the present study was to prepare and characterize controlled-release matrix tablets of zidovudine using hydrophilic HPMC K4 M or Carbopol 934 alone or in combination with hydrophobic ethyl cellulose. Release kinetics was evaluated by using USP XXIV dissolution apparatus No.2 (paddle) type. Scanning electron microscopy was used to visualize the effect of dissolution medium on matrix t...

Objective: Carvedilol is a non-selective beta blocker was formulated as microspheres by using Ethyl cellulose as a carrier. Methods: These ethyl cellulose microspheres were prepared by the solvent evaporation method. The prepared microspheres were subjected to various evaluation parameters and in vitro release studies. Highest percentage of entrapment was obtained by increasing the amount of po...