BACKGROUND The purpose of this study (GSK ADA111194) was to compare asthma-related health care utilization and costs associated with fluticasone propionate (an inhaled corticosteroid [ICS]) and salmeterol (a long-acting beta-agonist) in a single inhalation device (fluticasone propionate-salmeterol) versus the combination of ICS + montelukast in the treatment of pediatric patients with asthma. ...

Sir, Topical corticosteroids (TCS) are an integral part of dermatological therapeutics. The clinical effects of TCS depend on the structure of the molecule, the vehicle and the skin onto which it is applied.[1] Addition of a fluorine molecule at six and/ or nine positions enhances the potency of TCS. Halobetasol propionate has 6α flouro clobetasol 17-propionate as the active ingredient. Very oc...

Few thorough comparisons of the systemic effects of inhaled corticosteroids in children are available. The aim of this study was to compare the effect of budesonide and fluticasone propionate on short-term lower leg growth. Fluticasone propionate, budesonide and placebo were administered for 2 weeks in a randomized, double-blind, double-dummy, cross-over design. Twenty four children aged 6-12 y...

Milk-fed calves were used as a source of hepatocytes to establish monlayers to test the effects of chronic (41 h) incubation with no hormone, 100 nM insulin, or 100 nM glucagon on gluconeogenesis (glucose retained as glycogen plus glucose released into the medium) from 2.5 mM [2-(14)C]propionate and 2.0 mM [U-14C]lactate (1.0 mM lactate plus 1.0 mM pyruvate) during a subsequent 3-h (acute) incu...

Three lambs were used in a repeated Latin square design to determine the influence of isoenergetic infusions of propionate or glucose on portal-drained visceral flux (PDV) of nutrients and concentrations of insulin, glucagon, growth hormone and prolactin. Lambs were fitted with appropriate catheters for blood sampling and maintained on total intragastric infusion of nutrients. Basal VFA, casein...