BACKGROUND In trials designed to evaluate new therapies for hematologic malignancies, end points such as leukemia-free survival are often used as surrogates for overall survival in acute leukemia. We aimed to assess whether leukemia-free survival is an acceptable statistical surrogate for overall survival when applied to remission maintenance therapy for acute myeloid leukemia. DESIGN AND MET...

OBJECTIVE To determine whether the antiplatelet drug dilazep dihydrochloride affects the number of urinary podocytes in diabetic patients with microalbuminuria. RESEARCH DESIGN AND METHODS Fifty patients with type 2 diabetes and microalbuminuria (30 men and 20 women, mean age 48.6 years) and 30 age-matched control subjects (18 men and 12 women, mean age 49.2 years) were included in the study....

The usefulness of nuclear anomalies (NA) as a short-term test for indication of carcinogens in the mouse colon has been suggested previously by experiments in which colon-specific carcinogens induced NA in the colon, whereas non-colon carcinogens were, in general, impotent in that organ. We have extended this work to other sites in the digestive tract of female C57BL/6 mice treated with gamma-r...

The aim of this study was to evaluate the effectiveness of different irrigation solutions at different time intervals for the elimination of E. faecalis and C. albicans penetrated into the dentine tubules of primary and permanent teeth in vitro. The 4 mm primary and permanent teeth sections were sterilized and contaminated with a mixture of E. faecalis and C. albicans strains. After the applica...

Glucose. ...................... Sodium acetate (anhydrous). ... Salts A K~HPOI ..................... KHzPOr .................... Salts B MgSOa.7HzO. ................ MnS01.4H20. ............... NaCl ........................ FeSO,.7HzO .................. Adenine ....................... Guanine ....................... Uracil ......................... Thiamine chloride. ............. Pyridoxamine ...

s: Five new mixed-ligand nickel (II) complexes; viz; [Ni (BHM)(PMDT)]1; [Ni(BHM)(dien)] 2; [Ni(BHM)(L 1 )]3; [Ni(BHM)(L 2 )] 4, [Ni(BHM)(L 3 )] 5; where H2BHM= N ’ -(1E)-(5-bromo-2-hydroxyphenyl) methylidene] benzoylhydrazide, PMDT= N,N,N’,N, ” N ” -Pentamethyldiethylenetriamine; dien= diethylenetriamine; L 1 = N,Ndimethyl-N’ (Pyrid-2-yl-methyl) ethylenediamine; L 2 = N-methyl-N’-(pyrid-2ylmeth...

The dihydrochloride salt of pexidartinib was synthesized and the crystal structure its dihydrate determined from single data. asymmetric unit consists one formula unit. In molecule, N atom central pyridine ring pyridine-N pyrrolopyridine group are both protonated. molecule forms N–H···O N–H···Cl interactions with neighboring water molecules chloride ions, respectively. Water/chloride (O–H···Cl)...

The formation of /V-nitroso compounds in mouse stom ach from equimolar doses of sodium nitrite and secondary amines or alkylurea derivatives given simultaneously by a stomach tube was estimated by measuring the mutagenic activity of the compounds in the i.p. host-mediated assay with the use of Salmonella typhimurium TA1950 as genetic indicator system. A mutagenic response in the bacteria was fo...

In recent years, there has been much focus on research on non-dietary treatments in phenylketonuria (PKU). However, diet is likely to remain the major treatment for many years to come, since it has continued to be developed and consistent improvements have occurred. For example, with protein substitute, studies have tried to define the optimal dose and timing of intake; changes in palatability ...

A new family of nickel(II) complexes of the type [Ni(L)(CH(3)CN)](BPh(4))(2), where L=N-methyl-N,N',N'-tris(pyrid-2-ylmethyl)-ethylenediamine (L1, 1), N-benzyl-N,N',N'-tris(pyrid-2-yl-methyl)-ethylenediamine (L2, 2), N-methyl-N,N'-bis(pyrid-2-ylmethyl)-N'-(6-methyl-pyrid-2-yl-methyl)-ethylenediamine (L3, 3), N-methyl-N,N'-bis(pyrid-2-ylmethyl)-N'-(quinolin-2-ylmethyl)-ethylenediamine (L4, 4), a...