Objective(s):Estrogen (E2) has neuroprotective effects on blood-brain-barrier (BBB) after traumatic brain injury (TBI). In order to investigate the roles of estrogen receptors (ERs) in these effects, ER-α antagonist (MPP) and, ER-β antagonist (PHTPP), or non-selective estrogen receptors antagonist (ICI 182780) were administered. Materials and Methods: Ovariectomized rats were divided into 10 gr...

METHODS. Propranolol was administered subcutaneously and picropodophyllin (PPP) intraperitoneally. Intravitreal injections of vascular endothelial growth factor (VEGF) were performed. Messengers of -ARs, VEGF, its receptors, IGF-1 and IGF-1R were measured with quantitative RT-PCR. VEGF content was determined with ELISA. -ARs, hypoxia-inducible factor (HIF)-1 , occludin, and albumin were measure...

This study presents data which indicate that evisceration results in a marked decrease in the rate of disappearance of Evans Blue (T-1824) from the circulation of rabbits. Nephrectomy causes a significant increase in the rate of removal of dye from the blood stream. The possible explanations for these changes are considered, and the objections to the use of dye disappearance as a measure of cap...

The proteins, which bind albuminspecific dye Evans blue, are revealed in the low-molecular protein fraction of the blood serum from Scorpaena porcus L. and identified as serum albumin. They were represented by three bands in 2D-SDS-PAAG. MALDI-TOF-analysis revealed the fundamental similarity of the mass spectrum of the fragments of tryptic cleavage of proteins with molecular weight 73 and 76 kD...

Using retrograde transport of the fluorescent dye Evans Blue (EB), in combination with glyoxylic acid histofluorescence, the ponto-spinal catecholaminergic pathways were investigated. The cells which contain catecholamine and project to the lumbar spinal cord of the cat are most densely concentrated in the Kölliker-Fuse nucleus. Locus coeruleus, the subcoeruleus area, and the parabrachial nucle...

This study presents data which indicate that evisceration results in a marked decrease in the rate of disappearance of Evans Blue (T-1824) from the circulation of rabbits. Nephrectomy causes a significant increase in the rate of removal of dye from the blood stream. The possible explanations for these changes are considered, and the objections to the use of dye disappearance as a measure of cap...