The dominant orthodox biological concept of schizophrenia is that it is somehow related to an excess of dopamine activity in critical areas of the brain. The outstanding pieces of evidence in favor of this concept are that all the commonly used anti-schizophrenic drugs are blockers of dopamine receptors and that two groups have now reported that certain regions of the brain in schizophrenics ex...

Formulating etoposide into a nanoemulsion based on combining two natural oils, Ribes nigrum (black currant) seed oil and organic evening primrose oils may improve its antineoplastic activity in cancer cells. The present study aimed to synthesize, characterize vitro evaluate the cytotoxic effect of formulating etoposide-loaded Colorectal Carcinoma colon anti-proliferation anti-invasion effects p...

There is growing interest in plant polyphenols which exhibit pleiotropic biological activities, including anti-inflammatory, antioxidant, and anticancer effects. The objective of our study was to evaluate the influence of an evening primrose extract (EPE) from defatted seeds on viability and invasiveness of three human cell lines: PNT1A (normal prostate cells), DU145 (prostate cancer cells) and...

Nerve crush injuries are commonly used models for axonotmesis to examine peripheral nerve regeneration. As evening primrose oil (EPO) is rich in omega-6 essential fatty acid component and gamma-linolenic acid, studies have shown the potential role of EPO in myelination. Seventy-two healthy adult Sprague-Dawley rats were classified into three groups: normal group, control group, and experimental...