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OBJECTIVE Previous reports of the RAPID-axSpA trial (NCT01087762) described the efficacy and safety of certolizumab pegol (CZP) over 24 weeks in patients with axial spondyloarthritis (SpA), including ankylosing spondylitis (AS) and nonradiographic axial SpA. We report efficacy and safety data up to week 96 of the study. METHODS The RAPID-axSpA trial is double-blind and placebo-controlled to w...
BACKGROUND AND METHODS There are regular changes in mortality rates, such as increased rates of death from influenza in the winter and from motor vehicle accidents on long holiday weekends. Previous research has shown that among persons with schizophrenia, the rates of cocaine use and hospital admissions increase at the beginning of the month, after the receipt of disability payments. Using com...
OBJECTIVE The efficacy and safety of subcutaneous tocilizumab (TCZ-SC) versus subcutaneous placebo (PBO-SC) was evaluated in patients with rheumatoid arthritis who had an inadequate response to disease-modifying antirheumatic drugs in the BREVACTA study. METHODS Patients (n = 656) were randomized 2:1 to receive TCZ-SC 162 mg every other week or PBO-SC every other week for 24 weeks; 20% previo...
Experience matters. As Albert Einstein, Julius Caesar, and many other philosophers and wise men have said, experience is the one proven way to gain knowledge. Because experience matters so much, our profession must make every effort to make sure that each of us attains the experience necessary to best serve our patients. But these efforts are made more difficult because our hours in surgery hav...
a 3 × 3 factorial experiment with three levels of fennel extract (fe) (0, 50, and 100 mg/kg of diet) and three levels of added vitamin d3 (vit d3) (0, 3500 and 4200 iu/kg of diet), was carried out to evaluate reproductive performanceand immune response of post molted broiler breeders(76-84 weeks).broiler breeders were weighed at 10 week after molting (74 weeks) then randomly distributed into 36...
AIM The main aim of the present study was to explore the potential associations between dietary habits and the presence of overweight and obesity in Chilean adolescents. METHODS For the present study dietary habits of 21,385 Chilean students were analyzed and weight and height assessed, in order to determine potential associations between eating patterns and body mass index (BMI) values. RE...
Model-based meta-analysis of dose response is a sophisticated method to guide dose and regimen selection. In this report, the effects of paclitaxel dose and regimen (weekly or every 3 weeks) on the efficacy and safety in cancer patients were quantified by model-based meta-analysis of 29 monotherapy trials. Logistic regression models were developed to assess the relationship between dose and obj...
The most accepted method of secondary prophylaxis in rheumatic fever (RF) has been an injection of 1,200,000 units of benzathine penicillin G (BPG) every 4 weeks, but recurrences have been reported in some patients despite such a prophylaxis program. The WHO recommended BPG injections every 3 weeks in high risk patients and situations due to some published data in favor of inadequacy of on...
Sarcoidosis is characterised by non-caseating granulomas that secrete pro-inflammatory cytokines, including interleukin (IL)-12, IL-23, and tumour necrosis factor (TNF)-α. Ustekinumab and golimumab are monoclonal antibodies that specifically inhibit IL-12/IL-23 and TNF-α, respectively. Patients with chronic pulmonary sarcoidosis (lung group) and/or skin sarcoidosis (skin group) received either ...
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