Despite a heightened appreciation of the many defining molecular aberrations in Ewing sarcoma, the cooperative genetic environment and permissive cell of origin essential for EWS/ETS-mediated oncogenesis remain elusive. Consequently, inducible animal and in vitro models of Ewing sarcoma from a native cellular context are unable to fully recapitulate malignant transformation. Despite these short...

Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in aiding diagnosis and to complete the staging of bone cancer. In addition to these, there are several non-specific serological or specific mo...

A case of Ewing sarcoma in a 16-year-old girl with 47 XXXc karyotype is reported.

Ewing sarcoma (ES) is the second most common type of primary bone malignancy in children and young adults. Survival rates for localized ES have improved to upwards of 70% with aggressive chemotherapy and local control. On the other hand, there has been little improvement in survival rates for patients with metastatic or recurrent ES. Herein we review the different current therapeutic approaches...

Primary neoplasms of the skeleton are rare, amounting to only 0.2% of the overall human tumour burden. However, children are frequently affected and the aetiology is largely unknown. Significant progress has been made in the histological and genetic typing of bone tumours. Furthermore, advances in combined surgical and chemotherapy havelead to a significant increase in survival rates even for h...

• Patients with radiological findings suggesting a bone sarcoma should be referred without prior biopsy to a centre with particular bone sarcoma experience. Ewing’s sarcoma is usually dominated by a large soft tissue component. Histological diagnosis is made by needle biopsy or open surgical biopsy. The Ewing family of tumours (ES) includes classical Ewing’s sarcoma and primitive neuroectoderma...

Development of chemotherapeutic treatment modalities resulted in a dramatic increase in the survival of children with many types of cancer. Still, in case of some pediatric cancer entities including rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma, survival of patients remains dismal and novel treatment approaches are urgently needed. Therefore, based on the concept of targeted therapy, numer...

Ewing sarcoma is a rare primary neoplasm of bone representing approximately 6-8% all malignant tumours. Because its aggressive clinical behaviour and rapid dissemination to other sites, an early accurate diagnosis utmost importance. It shares morphological features with round cell tumors. Common differentials include lymphoblastic lymphoma, neuroblastoma, rhabdomyosarcoma neuroendocrine Due the...