Background and aim: Improvement of wound healing in normal subjects and in chronic ulcers has been always desired. The availablity and acceptability of herbal medicine led us to study the effect of topical 10% mucilage of quince seed in human skin.Materials and Methods: This double-blind clinical trial has been conducted on 34 patients referring to Imam Hospital, clinic...

The expression of native sonic hedgehog (Shh) was significantly increased in poly(methacrylic acid-co-methyl methacrylate) bead (MAA) treated wounds at day 4 compared to both poly(methyl methacrylate) bead (PMMA) treated and untreated wounds in diabetic db/db mice. MAA beads also increased the expression of the Shh transcription factor Gli3 at day 4. Previously, topical application of MAA beads...

The extracellular matrix polysaccharide hyaluronan (HA) plays a key role in both fibrotic and regenerative tissue repair. Accumulation of high molecular weight HA is typical of regenerative repair, which is associated with minimal inflammation and fibrosis, while fragmentation of HA is typical of postnatal wounds, which heal in the presence of inflammation and transient fibrosis. It is generall...

Physical treatments such as therapeutic ultrasound and Laser are cited as important aides in wound management. This work expected to assess the role of ultrasound and laser on excisional wound healing progression in incited diabetic mice. Forty Swiss albino mice were divided into 2 groups; group I (diabetic free, 10mice) was used as a control group, while the other; group II(30 mice) was diabet...

conclusions our results demonstrated the antimicrobial properties of frog skin as a wound dressing, which has antimicrobial effects per se. this biological dressing shows promise as an effective biological wound dressing insofar as not only is it capable of resisting microbes and accelerating wound healing but also it is cost-effective and easy to use. results in the microbial studies, the bact...

Monocytes and macrophages (m) are plastic cells whose functions are governed by microenvironmental cues. Wound fluid bathing the wound tissue reflects the wound microenvironment. Current literature on wound inflammation is primarily based on the study of blood monocyte-derived macrophages, cells that have never been exposed to the wound microenvironment. We sought to compare pair-matched monocy...